| Heat production and oxygen consumption of the isolated rabbit heart: their relation to mechanical function. | |
| | |
MedLine Citation:
|
PMID: 843319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A method is described for simultaneous determination of the heat production and the oxygen consumption of the isolated, isovolumetrically beating rabbit heart. The perfusion of the heart was performed via the aorta at a constant flow rate with carbogen saturated Tyrode's solution at a temperature of 37.0 degrees C. Heart function was varied by stepwise augmentation of the left intraventricular volume (LVV) by means of a balloon catheter. The following mechanical parameter of heart function were determined: enddiastolic pressure (EDP), peak pressure (PP), developed pressure (DP), max. contraction and relaxation velocity (dP/dt-A and dP/dt-B), enddiastolic tension (Tens-EDP), peak tension (Tens-PP), developed tension (Tens-DP), and circumferential tension (Tens-Cir). DP, dP/dt-A and dP/dt-R showed a maximum response to changes of the LVV at 2.0 ml LVV and 19.3 mm Hg EDP. Heat production (H) and oxygen consumption (Q) were correlated closely to mechanical function and to each other (r = 0.89, n = 8). The ratio H/Q was 4.9 cal/ml O2 and remained constant during the experiment. The myocardial energy consumption was significantly correlated toall contraction parameters with the best fit to DP and Tens-Cir (r = 0.934 and 0.933 resp.). On the basis of the calculated mean regression lines, the function-independent and the function-dependent energy consumption were calculated. |
| | |
Authors:
|
M Theisohn; M Friedrich; P Justus; K Güttler; W Klaus |
Related Documents
:
|
22664819 - Hypertension in bangladesh: a review. 22858239 - Dynamic vascular changes following intravenous antibiotics in patients with cystic fibr... 8788949 - Urinary bladder distension: its effects on carotid baroreceptor reflex left ventricular... 1390329 - Reduction of exercise-induced regional contractile dysfunction in dogs using a novel ca... 10639699 - Multivariate regression analysis of the influence of aortic pressure, end-diastolic pre... 22412779 - Assessment of the hemodynamic changes following fluid preloading in cardiac surgery. 16339819 - Comparison of the dual receptor endothelin antagonist enrasentan with enalapril in asym... 11240169 - Brain tissue po(2), pco(2), and ph during cerebral vasospasm. 8919619 - Measurement of dynamic pressures at the shoe-foot interface during normal walking with ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Basic research in cardiology Volume: 72 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1977 Jan-Feb |
Date Detail:
|
Created Date: 1977-04-30 Completed Date: 1977-04-30 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 19-33 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure Cardiac Volume Energy Metabolism* Hot Temperature Myocardial Contraction Myocardium / metabolism* Oxygen Consumption* Perfusion Rabbits Ventricular Function |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of acetylcholine on the regional distribution of microspheres in the skeletal muscle of the ...
Next Document: Norepinephrine, potassium and overdrive suppression.