| Heat production by brown adipocytes of FOK rats genetically resistant to a hot environment. | |
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MedLine Citation:
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PMID: 9450248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The FOK rat was established as an inbred strain with genotypic adaptation to a hot environment. To investigate the mechanism of the heat resistance of FOK rats, heat production by isolated brown adipocytes in FOK and WKAH rats was measured at 37.0 and 39.9 degrees C. Basal heat production by brown adipocytes of FOK rats was not significantly different from that of WKAH rats. Isoproterenol increased the heat production in a dose-dependent manner in both strains, while 10(-9) M isoproterenol caused a significant increase in WKAH rats and a negligible change in FOK rats. These results indicate that the reason why FOK rats are resistant to the severe heat is partly due to the low heat production by brown adipocytes. |
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Authors:
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E Tanaka; A Yamakawa; K Ito; M Yamamura; F Furuyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 59 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-03-17 Completed Date: 1998-03-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1157-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, Tokai University School of Medicine, Isehara, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology Adipose Tissue, Brown / anatomy & histology, cytology, physiology* Adrenergic beta-Agonists / pharmacology Animals Body Temperature Regulation / physiology* Body Weight / physiology Calorimetry Cells, Cultured Dose-Response Relationship, Drug Environment* Genotype Hot Temperature* Isoproterenol / pharmacology Male Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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