| Heat-escape behavior in the rat following intrahypothalamic injection of acetylcholine. | |
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MedLine Citation:
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PMID: 935208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of preoptic/anterior hypothalamic injections of acetylcholine on heat-escape behavior and hypothalamic temperature were investigated in unrestrained rats implanted with bilateral cannulae. Two types of responses were observed, either a fall in hypothalamic temperature coupled with an increase in behavioral responses to escape heat or a rise in hypothalamic temperature associated with little or no change in behavioral heat-escape responses. The fall in hypothalamic temperature observed in one group of rats was significant and was associated with a dose-dependent increase in heat-escape responding. The rise in hypothalamic temperature noted in the other group of rats was nonsignificant, and the associated behavioral responses were variable. Distinct anatomical differences in cannulae loci between the 2 groups were not apparent. It is concluded that acetylcholine activates the heat-dissipating control system of the rat hypothalamus and that the hyperthermic effects of acetylcholine are nonspecific. |
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Authors:
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M L Laudenslager; H J Carlisle |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 4 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1976 Apr |
Date Detail:
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Created Date: 1976-08-23 Completed Date: 1976-08-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 369-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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administration & dosage,
pharmacology* Animals Body Temperature Regulation* / drug effects Depression, Chemical Escape Reaction / drug effects* Hot Temperature Hypothalamus Injections Male Rats Reinforcement Schedule Time Factors |
| Chemical | |
Reg. No./Substance:
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51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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