| Heat capacity changes associated with nucleic acid folding. | |
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MedLine Citation:
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PMID: 16429398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whereas heat capacity changes (DeltaCPs) associated with folding transitions are commonplace in the literature of protein folding, they have long been considered a minor energetic contributor in nucleic acid folding. Recent advances in the understanding of nucleic acid folding and improved technology for measuring the energetics of folding transitions have allowed a greater experimental window for measuring these effects. We present in this review a survey of current literature that confronts the issue of DeltaCPs associated with nucleic acid folding transitions. This work helps to gather the molecular insights that can be gleaned from analysis of DeltaCPs and points toward the challenges that will need to be overcome if the energetic contribution of DeltaCP terms are to be put to use in improving free energy calculations for nucleic acid structure prediction. |
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Authors:
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Peter J Mikulecky; Andrew L Feig |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biopolymers Volume: 82 ISSN: 0006-3525 ISO Abbreviation: Biopolymers Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-06-14 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0372525 Medline TA: Biopolymers Country: United States |
Other Details:
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Languages: eng Pagination: 38-58 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2006 Wiley Periodicals, Inc. |
Affiliation:
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Department of Chemistry, Indiana University, 800 East Kirkwood Avenue Bloomington, IN 47401, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calorimetry, Differential Scanning DNA / chemistry* Hot Temperature* Hydrogen Bonding Models, Chemical Models, Molecular Nucleic Acid Conformation* Nucleic Acid Denaturation* RNA / chemistry* Thermodynamics |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM065430-05/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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