Document Detail


Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage.
MedLine Citation:
PMID:  20849898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Geldanamycin post-treatment is neuroprotective in the mouse model of intracerebral hemorrhage. Geldanamycin administration results in reduction of inflammation, preservation of blood-brain-barrier and amelioration of neurobehavioral deficits after an insult possibly by upregulation of heat shock protein 72.
Authors:
Anatol Manaenko; Nancy Fathali; Hank Chen; Hidenori Suzuki; Shammah Williams; John H Zhang; Jiping Tang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-09-16
Journal Detail:
Title:  Neurochemistry international     Volume:  57     ISSN:  1872-9754     ISO Abbreviation:  Neurochem. Int.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2011-09-07     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  844-50     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Physiology, Loma Linda University, Loma Linda, CA 92350, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzoquinones / pharmacology,  therapeutic use*
Brain Injuries / etiology,  metabolism*,  prevention & control*
Cerebral Hemorrhage / complications,  metabolism*,  prevention & control*
Disease Models, Animal*
HSP70 Heat-Shock Proteins / biosynthesis*
HSP72 Heat-Shock Proteins / biosynthesis
Lactams, Macrocyclic / pharmacology,  therapeutic use*
Male
Mice
Random Allocation
Up-Regulation / physiology*
Grant Support
ID/Acronym/Agency:
5R01NS60936-2/NS/NINDS NIH HHS; NS53407/NS/NINDS NIH HHS; R01 NS060936-01A2/NS/NINDS NIH HHS; R01 NS060936-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Benzoquinones; 0/HSP70 Heat-Shock Proteins; 0/HSP72 Heat-Shock Proteins; 0/Lactams, Macrocyclic; Z3K3VJ16KU/geldanamycin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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