Document Detail

Heartburn and regurgitation in pregnancy: the effect of fat ingestion.
MedLine Citation:
PMID:  19690957     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Reflux symptoms are common in pregnancy, but their association with fat ingestion is unclear. AIM: To investigate an association of dietary fats with heartburn and regurgitation in pregnancy. METHODS: This is a prospective study in which 89 pregnant women (gestational age 34 +/- 4 weeks) attending a low-risk prenatal outpatient clinic were asked to provide information on the frequency they experienced heartburn and regurgitation. Fat ingestion was estimated by means of a 24-h diet record. Symptomatic patients were compared with those with no reflux symptoms (n = 20). RESULTS: Heartburn once a week or more often occurred in 56 of the 89 patients (63%). The ingested amount of polyunsaturated fatty acids was higher in patients with heartburn (11.2 +/- 6.4 vs. 7.7 +/- 3.5 mg; P = 0.022) than in controls after adjusting for age, gain weight during pregnancy, ingestion of caffeine and vitamin C, and total energetic intake. The ingestion of monounsaturated fatty acids was higher in patients with heartburn, but with a borderline statistical significance (16.1 +/- 11 vs. 11.8 +/- 6.5 mg; P = 0.061). No association was observed between the consumption of fats and regurgitation. CONCLUSIONS: This study suggests that heartburn in the third trimester of pregnancy is associated with the ingestion of polyunsaturated fatty acids.
Valesca Dall'Alba; Fernando Fornari; Cláudio Krahe; Sidia Maria Callegari-Jacques; Sérgio Gabriel Silva de Barros
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-19
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  55     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1610-4     Citation Subset:  AIM; IM    
Post-Graduate Program, Sciences in Gastroenterology, School of Medicine and Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Rua Ramiro Barcelos, Porto Alegre, RS, Brazil.
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MeSH Terms
Case-Control Studies
Diet Records
Fatty Acids, Unsaturated / administration & dosage,  adverse effects*
Gastroesophageal Reflux / etiology*
Gestational Age
Heartburn / etiology*
Pregnancy Complications / etiology*
Pregnancy Trimester, Third
Prospective Studies
Risk Assessment
Risk Factors
Young Adult
Reg. No./Substance:
0/Fatty Acids, Unsaturated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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