| Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina. | |
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MedLine Citation:
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PMID: 21467182 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To investigate the cause of axial eye motion artifacts that occur in optical coherence tomography (OCT) imaging of the retina. Understanding the cause of these motions can lead to improved OCT image quality and therefore better diagnosis. Methods: 27 measurements were done on 5 subjects. We collected spectral-domain OCT images at the macula over periods up to 30 seconds. We calculated the axial shift of every average A-scan with respect to the previous average A-scan by calculating the cross-correlation. The frequency spectrum of the calculated shifts versus time was determined. The heart rate was determined from blood pressure measurements at the finger using an optical blood pressure detector. The fundamental frequency and higher order harmonics of the axial OCT shift were compared with the frequency spectrum of blood pressure data. In addition, simultaneous registration of the movement of the cornea and the retina was done using a dual reference arm OCT set-up and movements of the head were also analyzed. Results: We found a correlation of 0.90 between the fundamental frequency in the axial OCT shift and the heart rate. Cornea and retina move simultaneously in the axial direction. The entire head moves with the same amplitude as the retina. Conclusion: Axial motion artifacts during OCT volume scanning of the retina are caused by movements of the whole head induced by the heartbeat. |
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Authors:
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Roy de Kinkelder; Jeroen Kalkman; Dirk J Faber; Olaf Schraa; Pauline H B Kok; Frank D Verbraak; Ton G van Leeuwen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Biomedical Engineering & Physics, Academic Medical Center, University of Amsterdam, P.O. Box 22700, NL-1100 DE Amsterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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