| Heart valve sclerosis predicts all-cause and cardiovascular mortality. | |
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MedLine Citation:
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PMID: 19922935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Aortic valve sclerosis (AVS) and mitral annulus calcification (MAC) might predict future adverse events. We undertook the present study to investigate the association of AVS and MAC with all-cause and cardiovascular mortality. We further studied whether a combined presence of AVS and MAC is more strongly associated with mortality than the single items and sought to disclose possible gender differences in the investigated associations. METHODS: We used data from 2081 participants aged > or =45 years (1063 women) of the Study of Health in Pomerania (SHIP). AVS and MAC were determined echocardiographically, and a heart valve sclerosis score was calculated by summing up the AVS and MAC variables. The median duration of mortality follow-up was 8.6 years (17,162 person-years). RESULTS: There were 528 subjects (25.4%) with isolated AVS, 35 with isolated MAC (1.7%) and 89 with both AVS and MAC (4.3%). A total number of 228 deaths (11.0%) occurred during follow-up, including 133 (21.6%) with AVS and 95 subjects (6.5%) without AVS (incidence rate ratio 3.49, 95% CI 2.77; 4.40, p<0.001). Likewise, mortality rates were higher for subjects with MAC than subjects without MAC (incidence rate ratio 3.79, 95% CI 2.82; 5.02, p<0.001). Multivariable analyses revealed that the associations of AVS and MAC with all-cause and cardiovascular mortality were independent of major confounders and strongest for highest values of the heart valve sclerosis score. AVS-related mortality was more pronounced in women than in men. CONCLUSION: AVS and MAC are associated with all-cause and cardiovascular mortality. The association between AVS and mortality is gender-specific with women with AVS being at a higher mortality risk than men with AVS. The summation of AVS and MAC to a heart valve sclerosis score improves the predictability with respect to mortality. |
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Authors:
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Henry V?lzke; Robin Haring; Roberto Lorbeer; Henri Wallaschofski; Thorsten Reffelmann; Klaus Empen; Rainer Rettig; Ulrich John; Stephan B Felix; Marcus D?rr |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-29 |
Journal Detail:
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Title: Atherosclerosis Volume: 209 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-26 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 606-10 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Walther Rathenau Str. 48, D-17487 Greifswald, Germany. voelzke@uni-greifswald.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Valve / pathology Calcinosis / complications, mortality Cardiovascular Diseases / mortality* Cause of Death Echocardiography Female Germany / epidemiology Heart Valve Diseases / mortality*, pathology, ultrasonography Humans Male Middle Aged Mitral Valve / pathology* Sclerosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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