Document Detail

Heart valve replacement with St. Jude Medical valve prosthesis. Long-term experience in 743 patients in Switzerland.
MedLine Citation:
PMID:  3409515     Owner:  NLM     Status:  MEDLINE    
Between November 1978 and June 1986, 828 St. Jude Medical valves were implanted in 743 patients whose mean age was 57 years (range, 1-83 years) and who had been admitted to the University Hospitals in Basel, Berne, and Lausanne, Switzerland. Aortic valve replacement was performed in 456 patients, mitral valve replacement in 200, tricuspid valve replacement in six, double valve replacement in 77, and triple valve replacement in four. In 187 patients, additional surgical interventions were performed. Operative mortality was 1.6%, and the 4-week postoperative mortality was 4.0%. During a mean follow-up period of 2.6 years, the annual mortality rate was 3.1%, and the annual cardiac mortality rate was 2.1%. The thromboembolic rate per 100 patient-years was 1.3 after aortic valve replacement, 3.0 after mitral valve replacement, and 1.0 after multiple valve replacement. The incidence of major bleeding was 1.3 per 100 patient-years. Valve dysfunction attributable to thrombotic obstruction occurred in three patients, and that attributable to leaflet dislocation in one (annual dysfunction rate, 0.2%). Twelve patients developed infectious endocarditis, six of whom died. However, in four patients, reoperation and, in two patients, antibiotic treatment alone were successful in treating the infection. A paravalvular leak necessitating reoperation developed in 10 patients. In three patients, the leak was caused by infectious endocarditis. Reoperation had no operative mortality. In three patients (0.4%), a mild hemolytic anemia was found.(ABSTRACT TRUNCATED AT 250 WORDS)
D Burckhardt; D Striebel; S Vogt; A Hoffmann; J Roth; P Weiss; W Kiowski; M Pfisterer; F Burkart; U Althaus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  78     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-04     Completed Date:  1988-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I18-24     Citation Subset:  AIM; IM    
University Hospital Basel, Switzerland.
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MeSH Terms
Aged, 80 and over
Anemia, Hemolytic / etiology
Child, Preschool
Endocarditis, Bacterial / etiology
Heart Valve Diseases / mortality,  surgery*
Heart Valve Prosthesis*
Hemorrhage / etiology
Middle Aged
Postoperative Complications
Prosthesis Failure
Thromboembolism / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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