Document Detail

Heart valve involvement in familial amyloidosis with polyneuropathy.
MedLine Citation:
PMID:  3786249     Owner:  NLM     Status:  MEDLINE    
Involvement of the heart is common in the various types of amyloidosis. Little attention has, however, been paid to the presence and significance of amyloid in cardiac valves. We examined the heart valves of twelve autopsy cases with familial amyloidosis with polyneuropathy. All leaflets showed more or less abundant amyloid infiltration with significant valvular aortic stenosis due to degenerative calcification in two cases. In familial amyloidosis with polyneuropathy, amyloid deposits are thus invariably present in the valves, but the valvular function is often preserved. Amyloid may, however, produce hemodynamically significant valvular lesions, and the importance of valvular involvement in the various types of amyloidosis may still be underestimated.
A Eriksson; B O Olofsson; P Eriksson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology, research and practice     Volume:  181     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-20     Completed Date:  1987-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Amyloid / analysis
Amyloidosis / complications,  genetics*,  pathology
Heart Valve Diseases / complications*,  pathology
Heart Valves / analysis,  pathology*
Middle Aged
Nervous System Diseases / complications*,  pathology
Reg. No./Substance:

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