| Heart-type fatty acid-binding protein is a useful marker for organ dysfunction and leptin alleviates sepsis-induced organ injuries by restraining its tissue levels. | |
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MedLine Citation:
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PMID: 19576209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart-type fatty acid-binding protein (H-FABP) is widely distributed and has been used to diagnose certain diseases. However, its alteration during infection-evoked organ dysfunction, and the potential association between leptin and it in injury or infection has not been investigated. In the current study, serum H-FABP, leptin, C-reactive protein and interleukin-1beta in the patients with pulmonary infection-induced multiple organ dysfunction were detected. Moreover, a mouse model of sepsis was established, and serum alanine transaminase, uric acid, tissue H-FABP, myeloperoxidase, superoxide dismutase activity and histological alterations in lung and intestine were investigated. Serum H-FABP and leptin increased simultaneously and significantly in the patients, and leptin alleviated pulmonary and intestinal injuries by restraining tissue H-FABP secretions in the mouse model of sepsis. Other investigated variables showed different but independent alterations. In conclusion, H-FABP represents a useful diagnostic marker for organ dysfunction, and its association with leptin will be a novel target for emergency aid. |
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Authors:
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Guang-tao Yan; Ji Lin; Xiu-hua Hao; Hui Xue; Kai Zhang; Lu-huan Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-01 |
Journal Detail:
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Title: European journal of pharmacology Volume: 616 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 244-50 Citation Subset: IM |
Affiliation:
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Research Laboratory of Biochemistry, Basic Medical Institute, Chinese PLA General Hospital, Beijing, PR China. yan301@263.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Animals Biological Markers / blood C-Reactive Protein / metabolism Fatty Acid-Binding Proteins / analysis, blood*, metabolism* Female Humans Interleukin-1beta / blood Leptin / blood, pharmacology* Male Mice Middle Aged Multiple Organ Failure / blood, etiology*, pathology*, physiopathology Peroxidase / blood Rabbits Radioimmunoassay Reproducibility of Results Sepsis / complications*, metabolism Superoxide Dismutase / blood Uric Acid / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Interleukin-1beta; 0/Leptin; 69-93-2/Uric Acid; 9007-41-4/C-Reactive Protein; EC 1.11.1.7/Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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