| Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 16387818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether concentrations of heart-type fatty acid binding protein (H-FABP) measured before hospital discharge predict critical cardiac events in patients with idiopathic dilated cardiomyopathy (DCM). PATIENTS: 92 consecutive patients with DCM were enrolled and followed up for four years. MAIN OUTCOME MEASURES: Serum concentrations of H-FABP, brain natriuretic peptide (BNP), cardiac troponin T before hospital discharge and survival rate. RESULTS: 23 patients died of cardiac causes, received a left ventricular assist device or underwent heart transplantation during the four-year follow up. Univariate analyses showed that New York Heart Association functional class, heart rate, ejection fraction, serum H-FABP and plasma BNP were significant variables. According to multivariate analysis, serum H-FABP and plasma BNP concentrations were independent predictors of critical cardiac events. Cardiac troponin T before hospital discharge was not a predictor. The area under the receiver operating characteristic curve for death from critical cardiac events was similar between H-FABP and BNP. Patients with an H-FABP concentration at or above the median (> or = 5.4 ng/ml) had a significantly lower survival rate than those below the median, according to analysis by log rank test (p < 0.0001). When combined with BNP concentration at or above the median (> or = 138 pg/ml), H-FABP below the median predicted the worst prognosis among the combinations. CONCLUSIONS: The concentration of serum H-FABP before discharge from hospital may be an independent predictor for critical cardiac events in DCM. |
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Authors:
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K Komamura; T Sasaki; A Hanatani; J Kim; K Hashimura; Y Ishida; Y Ohkaru; K Asayama; T Tanaka; A Ogai; T Nakatani; S Kitamura; K Kangawa; K Miyatake; M Kitakaze |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-30 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 92 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-14 Completed Date: 2006-06-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 615-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute, Suita, Japan. kkoma@hsp.ncvc.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cardiomyopathy, Dilated / blood, mortality* Death, Sudden, Cardiac / etiology Fatty Acid-Binding Proteins / blood* Female Heart Rate / physiology Hospitalization Humans Male Middle Aged Natriuretic Peptide, Brain / blood Prognosis Stroke Volume / physiology Survival Rate Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Troponin T; 114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
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