Document Detail


Heart transplantation research in the next decade--a goal to achieving evidence-based outcomes: National Heart, Lung, And Blood Institute Working Group.
MedLine Citation:
PMID:  22464255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The National Heart, Lung, and Blood Institute (NHLBI) convened a Working Group (WG) on August 5 to 6, 2010 in Bethesda, Maryland to discuss future directions of research in heart transplantation (HT). The WG was composed of researchers with expertise in the basic science, clinical science, and epidemiological aspects of advanced heart failure and HT. These experts were asked to identify the highest priority research gaps in the field and make recommendations for future research strategies. The WG was also asked to include approaches that capitalize on current scientific opportunities and focus on areas that required unique NHLBI leadership. Finally, the WG was charged with developing recommendations that would have short- and long-term impact on the field of HT. The WG participants reviewed key areas in HT and identified the most urgent knowledge gaps. These gaps were then organized into the following 4 specific research directions: 1) enhanced phenotypic characterization of the pre-transplant population; 2) donor-recipient optimization strategies; 3) individualized immunosuppression therapy; and, 4) investigations of immune and non-immune factors affecting late cardiac allograft outcomes. Finally, because the HT population is relatively small compared with other patient groups, the WG strongly urged concerted efforts to enroll every transplant recipient into a clinical study and to increase collaborative networks to optimize research in this field.
Authors:
Monica R Shah; Randall C Starling; Lisa Schwartz Longacre; Mandeep R Mehra;
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  59     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-02     Completed Date:  2012-05-17     Revised Date:  2014-01-30    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1263-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Biomedical Research / standards,  trends*
Evidence-Based Medicine*
Forecasting
Graft Survival
Heart Transplantation / standards,  trends*
Humans
National Heart, Lung, and Blood Institute (U.S.)*
Transplantation Immunology
Treatment Outcome
United States
Grant Support
ID/Acronym/Agency:
U19 AI063603/AI/NIAID NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS
Investigator
Investigator/Affiliation:
Mark Barr / ; Howard Eisen / ; Gary Francis / ; John Fung / ; Kathleen Grady / ; Valluvan Jeevanandam / ; Maryl Johnson / ; Abdallah Kfoury / ; James Kirklin / ; Jon Kobashigawa / ; Robert Kormos / ; Joren Madsen / ; Donna Mancini / ; Bruce McManus / ; Christopher O'Connor / ; Marc Pfeffer / ; Richard Pierson / ; Elaine Reed / ; Daniel Salomon / ; Charles Steenbergen / ; Lynne Stevenson / ; LaRee Tracy / ; Liewei Wang /
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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