Document Detail


Heart transplantation at Cheng Hsin General Hospital in Taiwan: 15-year experience.
MedLine Citation:
PMID:  15561253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart transplantation (HTx) in Taiwan, which started in 1987, now includes more than 500 cases. From July 1988 to September 2003, we performed 215 cases of orthotopic HTx in 164 male and 51 female recipients of mean age of 47.3 +/- 14.3 years, (range 2.7 to 74.9 years). The leading etiologies were dilated cardiomyopathy (CMP), 68.5%; ischemic CMP, 20.2%; and valvular CMP, 4.2%. The actuarial survival rates at 1, 5, and 10 years are 88.3%, 77.1%, and 57.2%, respectively. We performed the first case of HTx in Asia after bridging for 14 days with an indigenous total artificial heart (TAH; the Phoenix-7 model); we performed the first case of infant HTx without blood transfusion and also the first case of autotransplantation of heart for repair of a left ventricular rupture after a mitral valve replacement. These cases were all successful with the longest surviving HTx recipient in Asia. We have used the biatrial anastomosis technique in all cases. We discovered familial CMP due to mitochondrial defects in two pediatric cases. Because of the scarcity of donor hearts, we have used size-mismatched hearts as well as suboptimal and hepatitis-positive donor hearts, all with satisfactory outcomes. Our experience has shown comparable results to Western programs, with efficacy and cost-effectiveness. We find the technique of biatrial anastomosis for orthotopic HTx to result in a low incidence of tricuspid regurgitation and conduction anomalies. The use of suboptimal and size-mismatched donor hearts is also promising.
Authors:
J Wei; C Y Chang; Y C Chuang; M S Young; C M Huang; W H Yin; D Y Tung; W C Lee; S L Lee; C H Chu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  36     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-11-24     Completed Date:  2005-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2374-6     Citation Subset:  IM    
Affiliation:
Heart Centre, Cheng Hsin General Hospital, Taipei, Taiwan, R.O.C. chghjw@yahoo.com.tw
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MeSH Terms
Descriptor/Qualifier:
Cause of Death
Follow-Up Studies
Graft Rejection / mortality
Heart Transplantation / mortality,  statistics & numerical data*
Humans
Postoperative Complications / classification
Retrospective Studies
Survival Analysis
Taiwan
Time Factors
Tricuspid Valve Insufficiency / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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