| Heart spotting. | |
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MedLine Citation:
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PMID: 18274799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac function depends upon several factors, including adequate cellular mass, intact contractile machinery, and adequate production of ATP. An appropriate homeostasis on all these levels is crucial for the daunting life-long task the myocardium faces. Not surprisingly, many alterations in the above factors have been spotted when the heart fails and hypothesized to play a causal role in the genesis of the failing heart. Indeed, development of cardiac hypertrophy and failure is associated with chamber remodeling as well as with changes of the phenotype at the level of the individual myocyte. Disturbed energy metabolism with impaired fatty acid oxidation and lower expression of proteins involved in ATP synthesis occurs during myocardial hypertrophy and heart failure. The altered expression of proteins from metabolic pathways may reflect mitochondrial dysfunction as a feature of the transition from compensated myocardial hypertrophy with preserved fatty acid metabolism to impaired energy metabolism in heart failure. |
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Authors:
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Hamid el Azzouzi; Leon J De Windt |
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Publication Detail:
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Type: Comment; Editorial; Research Support, Non-U.S. Gov't Date: 2008-02-15 |
Journal Detail:
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Title: Basic research in cardiology Volume: 103 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-16 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 228-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcineurin / metabolism Cardiomegaly / metabolism*, physiopathology Energy Metabolism* Heart Failure / metabolism*, physiopathology Humans Metabolomics Mitochondria, Heart / enzymology, metabolism* Myocardium / enzymology, metabolism* Ventricular Remodeling |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.16/Calcineurin |
| Comments/Corrections | |
Comment On:
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Basic Res Cardiol. 2008 May;103(3):232-43
[PMID:
18274801
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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