Document Detail

Heart sounds based measures of cardiac status for heart failure patient management.
MedLine Citation:
PMID:  19963791     Owner:  NLM     Status:  MEDLINE    
Heart sounds based measurements such as S3 amplitude and systolic timing intervals (STIs) are known to be indicative of cardiac dysfunction. In this paper we investigate the correlation of these measurements from pacemaker device implant locations to echocardiographic hemodynamic metrics of E wave deceleration time (EDT), Ejection Fraction (EF) and Stroke Volume (SV). Simultaneous heart sounds and echocardiography measurements were made in 6 heart failure patients with cardiac resynchronization therapy (CRT) devices prior to CRT activation (baseline) and at 3 and 6 months post-CRT. In N=17 datasets, S3 amplitude was correlated to EDT (r=-0.86, p<0.05). Similarly STIs such as heart sounds based pre-ejection period (HSPEP) was correlated with EF (r = -0.81, p<0.01) and ejection time (HSET) with SV (r = 0.65, p=0.01). Longitudinal analysis in each patient showed consistent changes between % increase in S3 vs. % decrease in EDT (r= -0.83, p<0.01), % change in HSPEP vs. % change in EF (r= -0.80, p=0.03) and % change in SV (r= -0.72, p< 0.01). These results show proof of concept for using pacemaker derived measurements for monitoring HF patients. Further study is needed to determine their efficacy for chronic monitoring of HF patients.
Abhilash Patangay; Kris Z Siejko; Ramesh Wariar; David B DeLurgio; Angel R Leon
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2009     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-16     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3016-9     Citation Subset:  IM    
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MeSH Terms
Echocardiography / methods
Feasibility Studies
Heart Failure / diagnosis,  physiopathology,  therapy*
Heart Sounds*
Middle Aged
Signal Processing, Computer-Assisted
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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