Document Detail


Heart repair and regeneration: recent insights from zebrafish studies.
MedLine Citation:
PMID:  22818295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease is the leading cause of death in the U.S. and worldwide. Failure to properly repair or regenerate damaged cardiac tissues after myocardial infarction is a major cause of heart failure. In contrast to humans and other mammals, zebrafish hearts regenerate after substantial injury or tissue damage. Here, we review recent progress in studying zebrafish heart regeneration, addressing the molecular and cellular responses in the three tissue layers of the heart: myocardium, epicardium, and endocardium. We also compare different injury models utilized to study zebrafish heart regeneration and discuss the differences in responses to injury between mammalian and zebrafish hearts. By learning how zebrafish hearts regenerate naturally, we can better design therapeutic strategies for repairing human hearts after myocardial infarction.
Authors:
Ching-Ling Lien; Michael R Harrison; Tai-Lan Tuan; Vaughn A Starnes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-07-20
Journal Detail:
Title:  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society     Volume:  20     ISSN:  1524-475X     ISO Abbreviation:  Wound Repair Regen     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-02-05     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9310939     Medline TA:  Wound Repair Regen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-46     Citation Subset:  IM    
Copyright Information:
© 2012 by the Wound Healing Society.
Affiliation:
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. clien@chla.usc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Diseases / pathology,  physiopathology
Cardiovascular Physiological Phenomena
Cell Proliferation
Endocardium / cytology,  physiology
Heart / physiology*,  physiopathology
Humans
Models, Animal
Myocardium / cytology
Myocytes, Cardiac* / physiology
Pericardium / cytology,  physiology
Regeneration*
Zebrafish*
Grant Support
ID/Acronym/Agency:
R01 HL096121/HL/NHLBI NIH HHS; R01GM055081/GM/NIGMS NIH HHS; R01HL096121/HL/NHLBI NIH HHS
Comments/Corrections

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