Document Detail


Heart regeneration.
MedLine Citation:
PMID:  21593865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure.
Authors:
Michael A Laflamme; Charles E Murry
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nature     Volume:  473     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-19     Completed Date:  2011-07-01     Revised Date:  2013-03-18    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  326-35     Citation Subset:  IM    
Affiliation:
Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Heart / growth & development,  physiology
Heart Failure / genetics,  pathology*,  surgery,  therapy*
Humans
Myocytes, Cardiac / cytology,  pathology
Nuclear Reprogramming
Regeneration / genetics,  physiology*
Regenerative Medicine* / methods
Stem Cell Transplantation
Grant Support
ID/Acronym/Agency:
R01 HL084642-06/HL/NHLBI NIH HHS; UL1 RR025014/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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