| Heart regeneration. | |
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MedLine Citation:
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PMID: 21593865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure. |
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Authors:
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Michael A Laflamme; Charles E Murry |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Nature Volume: 473 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-19 Completed Date: 2011-07-01 Revised Date: 2013-03-18 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 326-35 Citation Subset: IM |
Affiliation:
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Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart / growth & development, physiology Heart Failure / genetics, pathology*, surgery, therapy* Humans Myocytes, Cardiac / cytology, pathology Nuclear Reprogramming Regeneration / genetics, physiology* Regenerative Medicine* / methods Stem Cell Transplantation |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL084642-06/HL/NHLBI NIH HHS; UL1 RR025014/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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