Document Detail

Heart rate variation in patients treated with antidepressants. An index of anticholinergic effects?
MedLine Citation:
PMID:  6441956     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate whether heart rate variation as obtained simply from an electrocardiographic registration is influenced in subjects given antidepressive medication. The mean difference between consecutive R-R intervals (MCD) was reduced in patients (n = 23) treated with various doses of tri- or tetracyclic antidepressants [7.7 (1.8-32.3) ms in patients versus 24.8 (7.0-87.7) ms in controls]. Among those receiving 1.67 mg tricyclic antidepressant or more per kilogram body wt (n = 12) MCD was further reduced [5.0 (2.1-12.0) ms] with no overlapping of values as compared to controls (n = 9). In a subgroup of patients treated with clomipramine the MCD was related inversely to the dosage (R = 0.78, P less than 0.02). In an additional group of seven patients, MCD was reduced following a few days of treatment with antidepressants as compared to pretreatment values (P less than 0.02), indicating that the reduction is a result of therapy and not a concomitant of the affective state. We suggest that measurements of heart rate variation could be a useful tool to measure anticholinergic effects of antidepressants.
J Jakobsen; P Hauksson; P Vestergaard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  84     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1984  
Date Detail:
Created Date:  1985-03-25     Completed Date:  1985-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  544-8     Citation Subset:  IM    
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MeSH Terms
Age Factors
Antidepressive Agents / adverse effects*
Antidepressive Agents, Tricyclic / adverse effects
Heart Rate / drug effects*
Middle Aged
Sex Factors
Reg. No./Substance:
0/Antidepressive Agents; 0/Antidepressive Agents, Tricyclic; 0/Parasympatholytics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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