Document Detail


Heart rate variability and sympathetic skin response in male patients suffering from acute alcohol withdrawal syndrome.
MedLine Citation:
PMID:  16930222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many symptoms of alcohol withdrawal (AW) such as tachycardia or elevated blood pressure might be explained by increased peripheral and central adrenergic activity. In contrast to many neurochemical studies of sympathetic activation during AW, only very few studies investigated autonomic balance using neurophysiological methods. METHODS: We investigated heart rate variability (HRV) and sympathetic skin response (SSR) in male patients suffering from mild AW syndrome (n = 20, no treatment required) and in patients with moderate to severe AW syndrome (n = 20, clomethiazole treatment) in the acute stage. Sympathovagal influence was quantified using measures of time and frequency domain of HRV as well as modern nonlinear parameters (compression entropy). Furthermore, we obtained latencies and amplitudes of SSR to quantify isolated sympathetic influence. Measures were obtained during the climax of withdrawal symptomatology before treatment, 1 day after climax, and shortly before discharge from hospital. Alcohol withdrawal scores were obtained and correlated to autonomic measures. RESULTS: Ambulatory blood pressure and AW scores revealed characteristic withdrawal symptoms in both patient groups. Apart from the nonlinear parameter compression entropy, Hc, measures of HRV revealed no sign of autonomic dysfunction in contrast to the significantly increased heart rates at the time of admission. Latencies and amplitudes of SSR did not indicate any increase of sympathetic activity. A negative correlation was found between Hc and mental withdrawal symptoms. CONCLUSIONS: We show here that classical measures for autonomic nervous system activity such as HRV and SSR are not suitable for describing the autonomic changes seen in acute AW, although a major role for the sympathetic nervous system has been proposed. This might be due to multiple dysregulation of metabolites in AWS or to subtle alcohol-induced damage to neuronal structures, issues that should be addressed in future studies.
Authors:
Karl-Jürgen Bär; Michael Karl Boettger; Rene Neubauer; Marei Grotelüschen; Thomas Jochum; Vico Baier; Heinrich Sauer; Andreas Voss
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  30     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2006-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1592-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Friedrich-Schiller-University of Jena, Jena, Germany. karl-juergen.Baer@med.uni-jena.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Withdrawal Delirium / physiopathology
Autonomic Nervous System / physiology
Central Nervous System Depressants / adverse effects*
Chlormethiazole / therapeutic use
Ethanol / adverse effects*
GABA Modulators / therapeutic use
Galvanic Skin Response / physiology*
Heart Rate / physiology*
Humans
Male
Middle Aged
Nonlinear Dynamics
Substance Withdrawal Syndrome / drug therapy,  physiopathology*
Chemical
Reg. No./Substance:
0/Central Nervous System Depressants; 0/GABA Modulators; 533-45-9/Chlormethiazole; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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