Document Detail


Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease.
MedLine Citation:
PMID:  17383498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Depression is associated with an increased risk for cardiac morbidity and mortality in patients with coronary heart disease (CHD). Cardiac autonomic nervous system (ANS) dysregulation, proinflammatory processes, and procoagulant processes have been suggested as possible explanations.
METHODS: Heart rate variability (HRV), an indicator of cardiac autonomic regulation, and markers of inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha)] and coagulation (fibrinogen) were assessed in 44 depressed patients with CHD.
RESULTS: Moderate, negative correlations were found between fibrinogen and four measures of HRV. IL-6 also negatively correlated with one measure of HRV (total power) and was marginally related to two others (very low frequency and low frequency power). Neither CRP nor TNF-alpha was significantly related to any measure of HRV.
CONCLUSIONS: The finding that fibrinogen and IL-6 are moderately related to HRV suggests a link between these factors in depressed CHD patients. The relationship between ANS function and inflammatory and coagulant processes should be investigated in larger mechanistic studies of depression and cardiac morbidity and mortality.
Authors:
Robert M Carney; Kenneth E Freedland; Phyllis K Stein; Gregory E Miller; Brian Steinmeyer; Michael W Rich; Stephen P Duntley
Related Documents :
9462578 - Assessing baroreflex sensitivity in post-myocardial infarction patients: comparison of ...
17024498 - Inhalation of diluted diesel engine emission impacts heart rate variability and arrhyth...
20197118 - Epicardial neural ganglionated plexus of ovine heart: anatomic basis for experimental c...
9104918 - Prognostic value of heart rate variability in chronic congestive heart failure secondar...
891288 - Clinical significance of pulmonary function tests. pulmonary function after uncomplicat...
4025178 - Usefulness of left ventricular volume in assessing tetralogy of fallot for total correc...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychosomatic research     Volume:  62     ISSN:  0022-3999     ISO Abbreviation:  J Psychosom Res     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-07-16     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0376333     Medline TA:  J Psychosom Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Autonomic Nervous System / physiopathology
C-Reactive Protein / metabolism
Coronary Disease / blood*,  psychology*
Depression / blood*,  psychology*
Electrocardiography*
Female
Fibrinogen / metabolism*
Heart Rate / physiology*
Humans
Inflammation Mediators / blood*
Interleukin-6 / blood
Male
Middle Aged
Statistics as Topic
Tumor Necrosis Factor-alpha / blood
Grant Support
ID/Acronym/Agency:
R01 HL065356/HL/NHLBI NIH HHS; R01 HL65356/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fatigue, depressive symptoms, and hopelessness as predictors of adverse clinical events following pe...
Next Document:  Alterations in QT dispersion in the surface electrocardiogram of female adolescents diagnosed with r...