Document Detail

Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease.
MedLine Citation:
PMID:  17383498     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Depression is associated with an increased risk for cardiac morbidity and mortality in patients with coronary heart disease (CHD). Cardiac autonomic nervous system (ANS) dysregulation, proinflammatory processes, and procoagulant processes have been suggested as possible explanations.
METHODS: Heart rate variability (HRV), an indicator of cardiac autonomic regulation, and markers of inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha)] and coagulation (fibrinogen) were assessed in 44 depressed patients with CHD.
RESULTS: Moderate, negative correlations were found between fibrinogen and four measures of HRV. IL-6 also negatively correlated with one measure of HRV (total power) and was marginally related to two others (very low frequency and low frequency power). Neither CRP nor TNF-alpha was significantly related to any measure of HRV.
CONCLUSIONS: The finding that fibrinogen and IL-6 are moderately related to HRV suggests a link between these factors in depressed CHD patients. The relationship between ANS function and inflammatory and coagulant processes should be investigated in larger mechanistic studies of depression and cardiac morbidity and mortality.
Robert M Carney; Kenneth E Freedland; Phyllis K Stein; Gregory E Miller; Brian Steinmeyer; Michael W Rich; Stephen P Duntley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychosomatic research     Volume:  62     ISSN:  0022-3999     ISO Abbreviation:  J Psychosom Res     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-07-16     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0376333     Medline TA:  J Psychosom Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  463-7     Citation Subset:  IM    
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MeSH Terms
Autonomic Nervous System / physiopathology
C-Reactive Protein / metabolism
Coronary Disease / blood*,  psychology*
Depression / blood*,  psychology*
Fibrinogen / metabolism*
Heart Rate / physiology*
Inflammation Mediators / blood*
Interleukin-6 / blood
Middle Aged
Statistics as Topic
Tumor Necrosis Factor-alpha / blood
Grant Support
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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