Document Detail


Heart rate variability, left ventricular functions, and cardiac autonomic neuropathy in patients undergoing chronic hemodialysis.
MedLine Citation:
PMID:  14575292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Autonomic neuropathy and impairment of left ventricular functions (LVF) have been frequently encountered in chronic renal failure (CRF). The aim of the present study was to evaluate the relationship of cardiac autonomic modulation impairments, as assessed by means of heart rate variability (HRV), with clinical characteristics, and left ventricular function in the patients with CRF undergoing hemodialysis (HD). METHODS: Twenty control subjects (Group I) and 22 comparable by age and gender patients with CRF undergoing hemodialysis (Group II) were enrolled in the study. After routine clinical and biochemical evaluations, electrocardiography, and 2 Dimensional, M Mode echocardiography were performed in all participants. Frequency domain HRV analysis was studied by using Kardiosis System. The powers (P1 and P2) and the central frequencies (F1 and F2) of low and of high frequency spectral bands were recorded. RESULTS: End systolic (ESV) and end diastolic volumes (EDV) were significantly higher in Group II (59.3 +/- 21.1mL vs. 34.0 +/- 14.3 mL and 131.5 +/- 37.3 mL vs. 96.9 +/- 18.9 mL, p < 0.01, p < 0.05, respectively) when compared to those of Group I. Ejection fraction (EF) and fractional shortening (FS) were significantly lower in Group II than in control subjects (52.3 +/- 2.4% vs. 63.7 +/- 10.1% and 0.29 +/- 0.01 vs. 0.34 +/- 0.07, p < 0.001, p < 0.05, respectively). P and P2 were decreased in Group II than in Group I (136.2 +/- 173.9 m s2 vs. 911.0 +/- 685.5 and 96.5 +/- 149.6 vs. 499.7 +/- 679.5, p < 0.001, p < 0.01, respectively). Significant correlations were found between high frequency spectral power and dialysis duration (DD), ESV, EDV, EF, FS (r = 0.52 p < 0.01, r = 0.68 p < 0.001, r = 0.65 p < 0.002, r = 0.66 p < 0.02, and r = 0.69 p < 0.01). CONCLUSION: As a result, the dependence of cardiac autonomic neuropathy on the disease duration and degree of left ventricular function impairment was shown in the patients undergoing chronic hemodialysis.
Authors:
Ibrahim Karayaylali; Mustafa San; Gulmira Kudaiberdieva; Zarema Niyazova-Karben; Neslihan Seyrek; Mustafa Balal; Saime Paydas; Yahya Sagliker
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  25     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-24     Completed Date:  2004-02-18     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  845-53     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Medical Faculty, Cukurova University, Adana, Turkey. ibrahimk42@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System Diseases / complications,  physiopathology*
Female
Heart / physiopathology*
Heart Diseases / complications,  physiopathology*
Heart Rate / physiology*
Humans
Kidney Failure, Chronic / complications,  physiopathology*,  therapy
Male
Middle Aged
Renal Dialysis
Ventricular Function, Left / physiology*

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