Document Detail

Heart rate variability in severe right or left heart failure: the role of pulmonary hypertension and resistances.
MedLine Citation:
PMID:  14984725     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The decrease in heart rate variability (HRV) might be related to the hemodynamic status in heart failure. However, HRV in patients with severe isolated right heart failure has not been extensively studied.
AIMS: This study compared HRV in patients with congestive heart failure (CHF) and in patients with isolated right heart failure.
METHODS: Time and frequency domain analysis of HRV on 24-h ECG recording was assessed in 15 healthy subjects and in two groups of patients with severe heart failure awaiting heart or heart/lung transplantation. These were 15 patients with CHF due to idiopathic dilated cardiomyopathy (IDC) and 10 patients with isolated right heart failure due to primary pulmonary hypertension (PPH).
RESULTS: Measurement of HRV were significantly decreased in both groups of patients compared with the control group. Patients with IDC had higher pulmonary capillary wedge pressure than patients with PPH (P=0.04) but lower pulmonary artery pressure and lower pulmonary vascular resistance (PVR) (P<0.0001). However, all the measurements of HRV were significantly lower in patients with IDC than in patients with PPH (range 22-77%, P<0.05 to P<0.01). None of the HRV measurements correlated with filling pressure measurements.
CONCLUSIONS: The increase in pulmonary vascular resistance in heart failure is not the main causal factor behind a decrease in HRV.
Laurent Fauchier; Dominique Babuty; Alexandre Melin; Pierre Bonnet; Pierre Cosnay; Jean Paul Fauchier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  6     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-26     Completed Date:  2004-09-21     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
Service de Cardiologie B et Laboratoire d'Electrophysiologie Cardiaque, Centre Hospitalier Universitaire Trousseau, Tours, France.
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MeSH Terms
Arrhythmias, Cardiac / etiology
Cardiomyopathy, Dilated / etiology,  physiopathology*
Case-Control Studies
Electrocardiography, Ambulatory
Heart Rate / physiology*
Hypertension, Pulmonary / complications,  physiopathology*
Middle Aged
Pulmonary Wedge Pressure / physiology
Regression Analysis
Stroke Volume / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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