Document Detail

Heart rate variability in myotonic dystrophy type 1 patients.
MedLine Citation:
PMID:  22406991     Owner:  NLM     Status:  Publisher    
BACKGROUND: Cardiac involvement is common in myotonic dystrophy (MD) patients. Heart rate variability (HRV) is a simple and reliable technique that can be useful for studying the influence of the autonomic nervous system on the heart. OBJECTIVE: Study heart rate variability in patients with type 1 MD. METHODS: We studied HRV during 5-minute recordings in MD patients and in a healthy control group. We analyzed frequency domains (LF and HF) in normalized units (nu) and sympathovagal balance, in the sitting and supine position. RESULTS: Seventeen patients (10 men and 7 women) and seventeen matched healthy individuals (10 men and 7 women) were studied. Sympathetic and parasympathetic modulations of the heart increased in male MD patients from supine to sitting position in 19% of LFnu and the LF/HF ratio rose by 42.3%. In the sitting position, male MD patients exhibited significantly higher sympathovagal balances in 50.9% compared to healthy control individuals. HRV was influenced by both gender and disease. Gender influenced LFnu in the supine position while the LF/HF ratio and HFnu were affected in both positions. Post hoc analyses showed that gender significantly impacts MD patients and healthy individuals in different ways (p < 0.01). The low frequency domain in the sitting position (LFnu) was significantly influenced by the disease. CONCLUSION: The results of this study suggest that the sympathetic drive in middle-aged male MD patients who are not severely impaired and present moderate disease duration seems to be greater than in healthy matched individuals.
Guilherme Fregonezi; Thaise Araújo; Mario Emilio Dourado Junior; Joceline Ferezini; Ester Silva; Vanessa Resqueti
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-08
Journal Detail:
Title:  Arquivos brasileiros de cardiologia     Volume:  -     ISSN:  1678-4170     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421031     Medline TA:  Arq Bras Cardiol     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  -     Citation Subset:  -    
Laboratório de Fisioterapia Pneumocardiovascular, Departamento de Fisioterapia, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, RN.
Vernacular Title:
Variabilidade da frequência cardíaca em pacientes com Distrofia Miotônica tipo 1.
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