Document Detail

Heart rate variability in left ventricular hypertrophy.
MedLine Citation:
PMID:  7696023     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Electrocardiographic left ventricular hypertrophy and strain are associated with increased cardiac morbidity and mortality. Impaired cardiac autonomic function, assessed non-invasively by spontaneous heart rate variability on Holter monitoring, is associated with an increased risk of sudden death after myocardial infarction. AIM: To study the effect of left ventricular hypertrophy on heart rate variability. PATIENTS: 36 controls and 154 patients with left ventricular hypertrophy (94 with hypertension and 60 with aortic valve disease). SETTING: Tertiary referral centre. METHODS: Heart rate variability was measured on 24 h Holter recordings by non-spectral methods. Left ventricular mass index and fractional shortening were measured by echocardiography. RESULTS: Patients with left ventricular hypertrophy had a higher left ventricular mass index (P < 0.001) and reduced heart rate variability (P < 0.001) compared with those of the controls. A continuous inverse relation was apparent between heart rate variability and left ventricular mass index (r = -0.478, P < 0.001). Heart rate variability was not affected by age, the presence of coronary artery disease in patients with left ventricular hypertrophy, or beta blocker treatment for hypertension. Multivariate analysis showed that left ventricular mass index is the most important determinant of heart rate variability. CONCLUSION: Heart rate variability is significantly reduced in patients with left ventricular hypertrophy secondary to hypertension or aortic valve disease. A continuous inverse relation exists between heart rate variability and left ventricular mass index. Impaired cardiac autonomic function in left ventricular hypertrophy may contribute to the mechanism of sudden death.
M K Mandawat; D R Wallbridge; S D Pringle; A A Riyami; S Latif; P W Macfarlane; A R Lorimer; S M Cobbe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British heart journal     Volume:  73     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-05-04     Completed Date:  1995-05-04     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  AIM; IM    
Department of Medical Cardiology, Royal Infirmary, Glasgow.
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MeSH Terms
Aortic Valve Stenosis / physiopathology,  ultrasonography
Coronary Angiography
Electrocardiography, Ambulatory
Heart Rate / physiology*
Hypertension / physiopathology,  ultrasonography
Hypertrophy, Left Ventricular / physiopathology*,  ultrasonography
Middle Aged
Multivariate Analysis
Comment In:
Br Heart J. 1995 Dec;74(6):702   [PMID:  8541185 ]

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