Document Detail

Heart rate variability in atrial fibrillation related to left atrial size.
MedLine Citation:
PMID:  15019873     Owner:  NLM     Status:  MEDLINE    
The purpose of this investigation was to determine whether heart rate variability (HRV) in atrial fibrillation (AF) can be related to any echocardiographic-derived measurements of cardiac dimensions or function. AF is characterized by marked HRV. Although HRV in normal sinus rhythm has been studied and shown to have important clinical implications, there have been relatively few published reports dealing with the phenomenon in AF. This study examines HRV in AF taking into account the influence of heart rate. HRV measurements were obtained in 38 patients with persistent AF who had undergone 24-hour ambulatory electrocardiographic monitoring. Taking into account a strong heart rate dependence of the HRV measurements, regressions were calculated. The relations were then re-examined using the differences (diff) in HRV from the expected for the average RR intervals. No significant correlations were found between unadjusted HRV measurements and any clinical features or echocardiographic variables. However, taking into account heart rate relations, with negative HRVdiff signifying less HRV than expected, reduced HRV correlated with increasing left atrial and left ventricular dimensions. On multivariate regression analysis, left atrial dimension emerged as an independent determinant of HRV. Also, HRV was greater in patients with lone AF than in those with cardiac disorders. HRV in AF is highly rate dependent. Unless this influence is taken into account, important relations may be obscured. When HRVdiff are related to echocardiographic measurements, increasing left atrial dimensions correlate with less HRV.
Howard S Friedman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  93     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-15     Completed Date:  2004-04-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  705-9     Citation Subset:  AIM; IM    
Division of Cardiology and Department of Medicine, New York University School of Medicine, New York, New York 10016, USA.
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MeSH Terms
Atrial Fibrillation / physiopathology*
Atrial Function
Electrocardiography, Ambulatory
Heart Atria / pathology,  physiopathology,  ultrasonography*
Heart Rate / physiology*

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