Document Detail

Heart rate variability estimates of autonomic tone: relationship to mapping pathological and procedural stress responses in coronary disease.
MedLine Citation:
PMID:  15513296     Owner:  NLM     Status:  MEDLINE    
Many lines of experimental evidence suggest the interplay of the autonomic nervous system and a variety of mediators of vascular atheroma and ultimately vascular occlusion. In vivo study in human volunteers and patients is hampered by the lack of a reliable and sensitive marker of prevailing autonomic tone able to reflect the appropriate dynamic change in nervous activity. Currently, the modern standard for definition of autonomic tone is based on a variety of analyses of R-R interval variability from the surface ECG. In this review, we consider whether heart rate variability techniques are sensitive enough to define relevant clinical interactions between neural tone and other mediators of vascular occlusion--specifically, mechanical pressure, thrombotic and hormonal factors--which are relevant to atherosclerotic vascular disease.
Ali Hamaad; Gregory Y H Lip; Robert J MacFadyen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of medicine     Volume:  36     ISSN:  0785-3890     ISO Abbreviation:  Ann. Med.     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-02-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  448-61     Citation Subset:  IM    
From the University Department of Medicine, City Hospital, Birmingham United Kingdom.
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MeSH Terms
Age Factors
Angioplasty, Balloon
Coronary Disease / physiopathology*,  therapy
Electrocardiography, Ambulatory
Heart Rate / physiology*
Myocardial Infarction / physiopathology
Sex Factors
Stress, Psychological / physiopathology
Sympathetic Nervous System / physiopathology*
Ventricular Dysfunction, Left / physiopathology,  therapy

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