| Heart rate variability and electrocardiogram waveform as predictors of morbidity during hypothermia and rewarming in rats. | |
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MedLine Citation:
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PMID: 12430988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined electrocardiogram (ECG) waveform, heart rate (HR), mean blood pressure (BP), and HR variability as potential autonomic signatures of hypothermia and rewarming. Adult male Sprague-Dawley rats had telemetry transmitters surgically implanted, and 2 weeks were allowed for recovery prior to induction of hypothermia. Rats were lightly anesthetized (sodium pentobarbital, 35 mg/kg i.p.) and placed in a coil of copper tubing through which temperature-controlled water was circulated. Animals were cooled to a core temperature (Tc) of 20 degrees C, maintained there for 30 min, and then rewarmed. Data (Tc, BP, HR from ECG, and 10-s strips of ECG waveforms) were collected every 5 min throughout hypothermia and rewarming. Both HR and BP declined after initial increases with the drop in HR starting at a higher Tc than the drop in BP (29.6 +/- 2.4 degrees C vs. 27.1 +/- 3.3 degrees C, p < 0.05). Animals that were not successfully rewarmed exhibited a significant (p < 0.05) increase in the normalized standard deviation of interbeat intervals (IBI) throughout cooling compared with animals that were successfully rewarmed. The T wave of the ECG increased in amplitude and area with decreasing Tc. T-wave amplitude and IBI variability show potential as predictors of survival in hypothermic victims. |
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Authors:
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C B Matthew; A M Bastille; R R Gonzalez; I V Sils |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 80 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-11-14 Completed Date: 2003-04-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: Canada |
Other Details:
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Languages: eng Pagination: 925-33 Citation Subset: IM |
Affiliation:
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U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007, USA. candace.matthew@na.amedd.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Body Temperature / physiology Electrocardiography* / statistics & numerical data Heart Rate / physiology* Hypothermia / mortality, physiopathology* Male Predictive Value of Tests Rats Rats, Sprague-Dawley Rewarming / methods*, statistics & numerical data |
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