Document Detail

Heart rate variability and electrocardiogram waveform as predictors of morbidity during hypothermia and rewarming in rats.
MedLine Citation:
PMID:  12430988     Owner:  NLM     Status:  MEDLINE    
This study examined electrocardiogram (ECG) waveform, heart rate (HR), mean blood pressure (BP), and HR variability as potential autonomic signatures of hypothermia and rewarming. Adult male Sprague-Dawley rats had telemetry transmitters surgically implanted, and 2 weeks were allowed for recovery prior to induction of hypothermia. Rats were lightly anesthetized (sodium pentobarbital, 35 mg/kg i.p.) and placed in a coil of copper tubing through which temperature-controlled water was circulated. Animals were cooled to a core temperature (Tc) of 20 degrees C, maintained there for 30 min, and then rewarmed. Data (Tc, BP, HR from ECG, and 10-s strips of ECG waveforms) were collected every 5 min throughout hypothermia and rewarming. Both HR and BP declined after initial increases with the drop in HR starting at a higher Tc than the drop in BP (29.6 +/- 2.4 degrees C vs. 27.1 +/- 3.3 degrees C, p < 0.05). Animals that were not successfully rewarmed exhibited a significant (p < 0.05) increase in the normalized standard deviation of interbeat intervals (IBI) throughout cooling compared with animals that were successfully rewarmed. The T wave of the ECG increased in amplitude and area with decreasing Tc. T-wave amplitude and IBI variability show potential as predictors of survival in hypothermic victims.
C B Matthew; A M Bastille; R R Gonzalez; I V Sils
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  80     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-11-14     Completed Date:  2003-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  925-33     Citation Subset:  IM    
U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760-5007, USA.
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MeSH Terms
Blood Pressure / physiology
Body Temperature / physiology
Electrocardiography* / statistics & numerical data
Heart Rate / physiology*
Hypothermia / mortality,  physiopathology*
Predictive Value of Tests
Rats, Sprague-Dawley
Rewarming / methods*,  statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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