Document Detail

Heart rate variability during massive hemorrhage and progressive hemorrhagic shock in dogs.
MedLine Citation:
PMID:  10958100     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the sequential changes in heart rate (HR), autonomic nervous activity presented by the spectral analysis of heart rate variability (HRV), hemodynamics and metabolism during massive hemorrhage and progressive hemorrhagic shock in dogs. METHODS: Twelve dogs were subjected to acute massive hemorrhage until mean arterial pressure (MAP) reached 50 mm Hg. Then bleeding was stopped and they were allowed to reach a plateau phase. They were divided, post hoc, into bradycardic or tachycardic groups according to their HR response to the acute massive hemorrhage. After reaching a plateau phase, the dogs were further bled to keep their MAP around 50 mmHg (progressive hemorrhagic shock). Their heart rate power spectra were quantified into low-frequency (LF) (0.04-0.15 Hz) and high-frequency (HF) (0.15-0.4 Hz) components. RESULTS: In the bradycardic group, both LF and HF increased after massive hemorrhage, but during progressive hemorrhagic shock these components decreased while HR increased. In the tachycardic group, LF increased after massive hemorrhage, but during progressive hemorrhagic shock LF decreased with continuous suppression of HF CONCLUSION: Massive hemorrhage caused two types of HR response: bradycardia and tachycardia. The HRV profile showed differential autonomic characteristics, and could be a valuable tool in assessing various degrees of hemorrhagic shock.
M Kawase; T Komatsu; K Nishiwaki; T Kimura; Y Fujiwara; T Takahashi; Y Shimada
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  47     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-07     Completed Date:  2000-12-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  807-14     Citation Subset:  IM    
Department of Anesthesiology, Nagoya University School of Medicine, Japan.
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MeSH Terms
Blood Pressure
Cardiac Output
Heart Rate*
Hemorrhage / physiopathology*
Oxygen / blood
Shock, Hemorrhagic / physiopathology*
Reg. No./Substance:

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