| Heart rate variability and diastolic heart failure. | |
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MedLine Citation:
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PMID: 15009853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diastolic heart failure accounts for up to 40% of patients with congestive heart failure (CHF), and is associated with a better prognosis as compared to patients with systolic dysfunction. Nevertheless, patients with diastolic dysfunction have a significantly higher mortality as compared to the normal population. Reduced heart rate variability (HRV), a marker of autonomic dysfunction, is associated with increased mortality in patients with systolic heart failure. We therefore sought to determine to what extent HRV is altered in a population of patients with diastolic heart failure. Twenty-four hour ambulatory (Holter) recordings were performed in 19 consecutive patients with diastolic heart failure, in 9 patients with systolic heart failure, as well as in 9 healthy volunteers (normal controls). Time and frequency domain HRV variables were obtained for all three groups of patients. Both Time and Frequency domain variables were found to be reduced in both heart failure groups compared to normal controls. When compared with each other, patients with diastolic function had relatively higher values of HRV variables, compared to those with systolic dysfunction (SDNN, Total power, ULF power, all P <or= 0.05). Patients with diastolic dysfunction have reduced HRV, suggesting a disturbed sympathetic-parasympathetic balance. Nevertheless, values for HRV are not as profoundly reduced as in patients with systolic dysfunction. The relative preservation of sympathetic-parasympathetic balance may explain the better prognosis in this patient population. |
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Authors:
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Rishi Arora; Andrew Krummerman; Pugazhendihi Vijayaraman; Michael Rosengarten; Vana Suryadevara; Thierry Lejemtel; Kevin J Ferrick |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 27 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-10 Completed Date: 2004-07-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 299-303 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Autonomic Nervous System Diseases / physiopathology Cause of Death Diastole / physiology Electrocardiography, Ambulatory Female Follow-Up Studies Heart Failure / physiopathology* Heart Rate / physiology* Humans Male Middle Aged Parasympathetic Nervous System / physiopathology Prognosis Sympathetic Nervous System / physiopathology Systole / physiology Time Factors |
| Comments/Corrections | |
Comment In:
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Pacing Clin Electrophysiol. 2004 Sep;27(9):1333; author reply 1333
[PMID:
15461733
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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