Document Detail

Heart rate variability and diastolic heart failure.
MedLine Citation:
PMID:  15009853     Owner:  NLM     Status:  MEDLINE    
Diastolic heart failure accounts for up to 40% of patients with congestive heart failure (CHF), and is associated with a better prognosis as compared to patients with systolic dysfunction. Nevertheless, patients with diastolic dysfunction have a significantly higher mortality as compared to the normal population. Reduced heart rate variability (HRV), a marker of autonomic dysfunction, is associated with increased mortality in patients with systolic heart failure. We therefore sought to determine to what extent HRV is altered in a population of patients with diastolic heart failure. Twenty-four hour ambulatory (Holter) recordings were performed in 19 consecutive patients with diastolic heart failure, in 9 patients with systolic heart failure, as well as in 9 healthy volunteers (normal controls). Time and frequency domain HRV variables were obtained for all three groups of patients. Both Time and Frequency domain variables were found to be reduced in both heart failure groups compared to normal controls. When compared with each other, patients with diastolic function had relatively higher values of HRV variables, compared to those with systolic dysfunction (SDNN, Total power, ULF power, all P <or= 0.05). Patients with diastolic dysfunction have reduced HRV, suggesting a disturbed sympathetic-parasympathetic balance. Nevertheless, values for HRV are not as profoundly reduced as in patients with systolic dysfunction. The relative preservation of sympathetic-parasympathetic balance may explain the better prognosis in this patient population.
Rishi Arora; Andrew Krummerman; Pugazhendihi Vijayaraman; Michael Rosengarten; Vana Suryadevara; Thierry Lejemtel; Kevin J Ferrick
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  27     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-07-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-303     Citation Subset:  IM    
Division of Cardiology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA.
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MeSH Terms
Analysis of Variance
Autonomic Nervous System Diseases / physiopathology
Cause of Death
Diastole / physiology
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Failure / physiopathology*
Heart Rate / physiology*
Middle Aged
Parasympathetic Nervous System / physiopathology
Sympathetic Nervous System / physiopathology
Systole / physiology
Time Factors
Comment In:
Pacing Clin Electrophysiol. 2004 Sep;27(9):1333; author reply 1333   [PMID:  15461733 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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