| Heart rate variability declines with increasing age and CTG repeat length in patients with myotonic dystrophy type 1. | |
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MedLine Citation:
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PMID: 14510658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cardiac myopathy manifesting as arrhythmias is common in the neurological disease, myotonic dystrophy type 1 (DM1). The purpose of the present study was to evaluate heart rate variability (HRV) in patients with DM1. METHODS: In a multicenter study, history, ECG, and genetic testing were performed in DM1 patients. RESULTS: In 289 patients in whom the diagnosis of DM1 was confirmed by a prolonged cytosine-thymine-guanine (CTG) repeat length the most common ambulatory ECG abnormality was frequent ventricular ectopy (16.3%). The 24-hour time domain parameters of SDNN (SD of the NN interval) and SDANN (SD of the mean NN, 5-minute interval) declined as age and CTG repeat length increased (SDNN: -8.5 ms per decade, 95% confidence intervals [CI]-12.9, -4.2, -8.7 ms per 500 CTG repeats, CI -15.7, -1.8, r=0.24, P<0.001; SDANN: -8.1 ms per decade, CI -12.4, -3.8, -8.8 ms per 500 CTG repeats, CI -15.7, -1.9, r=0.23, P<0.001). Short-term frequency domain parameters declined with age only (total power: -658 ms2 per decade, CI: -984, -331, r=0.23, P<0.001; low frequency (LF) power -287 ms2 per decade, CI: -397, -178, r=0.30, P<0.001; high frequency (HF) power: -267 ms2 per decade, CI: -386, -144, r=0.25, P<0.001). The LF/HF ratio increased as the patient aged (0.5 per decade, CI: 0.1, 0.9, r=0.13, P=0.03). CONCLUSIONS: In DM1 patients a decline in HRV is observed as the patient ages and CTG repeat length increases. |
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Authors:
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Bradley A Hardin; Miriam R Lowe; Deepak Bhakta; William J Groh |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 8 ISSN: 1082-720X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-09-26 Completed Date: 2004-03-19 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
Affiliation:
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Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Arrhythmias, Cardiac / epidemiology, genetics, physiopathology Autonomic Nervous System / physiology Electrocardiography, Ambulatory Female Follow-Up Studies Genetic Markers / genetics Genetic Predisposition to Disease / genetics Guanine / physiology* Heart Conduction System / pathology, physiopathology Heart Rate / genetics* Humans Male Middle Aged Multivariate Analysis Myotonic Dystrophy / epidemiology, genetics*, physiopathology Observer Variation Pyrimidine Dimers / genetics* Registries Statistics as Topic Trinucleotide Repeat Expansion / genetics Trinucleotide Repeats / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00750-27S1/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 0/Pyrimidine Dimers; 73-40-5/Guanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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