Document Detail

Heart rate variability declines with increasing age and CTG repeat length in patients with myotonic dystrophy type 1.
MedLine Citation:
PMID:  14510658     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiac myopathy manifesting as arrhythmias is common in the neurological disease, myotonic dystrophy type 1 (DM1). The purpose of the present study was to evaluate heart rate variability (HRV) in patients with DM1. METHODS: In a multicenter study, history, ECG, and genetic testing were performed in DM1 patients. RESULTS: In 289 patients in whom the diagnosis of DM1 was confirmed by a prolonged cytosine-thymine-guanine (CTG) repeat length the most common ambulatory ECG abnormality was frequent ventricular ectopy (16.3%). The 24-hour time domain parameters of SDNN (SD of the NN interval) and SDANN (SD of the mean NN, 5-minute interval) declined as age and CTG repeat length increased (SDNN: -8.5 ms per decade, 95% confidence intervals [CI]-12.9, -4.2, -8.7 ms per 500 CTG repeats, CI -15.7, -1.8, r=0.24, P<0.001; SDANN: -8.1 ms per decade, CI -12.4, -3.8, -8.8 ms per 500 CTG repeats, CI -15.7, -1.9, r=0.23, P<0.001). Short-term frequency domain parameters declined with age only (total power: -658 ms2 per decade, CI: -984, -331, r=0.23, P<0.001; low frequency (LF) power -287 ms2 per decade, CI: -397, -178, r=0.30, P<0.001; high frequency (HF) power: -267 ms2 per decade, CI: -386, -144, r=0.25, P<0.001). The LF/HF ratio increased as the patient aged (0.5 per decade, CI: 0.1, 0.9, r=0.13, P=0.03). CONCLUSIONS: In DM1 patients a decline in HRV is observed as the patient ages and CTG repeat length increases.
Bradley A Hardin; Miriam R Lowe; Deepak Bhakta; William J Groh
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  8     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-09-26     Completed Date:  2004-03-19     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-32     Citation Subset:  IM    
Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
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MeSH Terms
Age Factors
Arrhythmias, Cardiac / epidemiology,  genetics,  physiopathology
Autonomic Nervous System / physiology
Electrocardiography, Ambulatory
Follow-Up Studies
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics
Guanine / physiology*
Heart Conduction System / pathology,  physiopathology
Heart Rate / genetics*
Middle Aged
Multivariate Analysis
Myotonic Dystrophy / epidemiology,  genetics*,  physiopathology
Observer Variation
Pyrimidine Dimers / genetics*
Statistics as Topic
Trinucleotide Repeat Expansion / genetics
Trinucleotide Repeats / genetics*
Grant Support
M01-RR00750-27S1/RR/NCRR NIH HHS
Reg. No./Substance:
0/Genetic Markers; 0/Pyrimidine Dimers; 73-40-5/Guanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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