Document Detail

Heart rate variability by triangular index in infants exposed prenatally to cocaine.
MedLine Citation:
PMID:  12431317     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In adults, heart rate variability triangular index (HRVi) is a highly reproducible measure of heart rate variability (HRV), which makes it more suitable for use in longitudinal studies. Although normative data have been published for newborns, studies in infants with pathological conditions are lacking. METHODS: From 1997 to 2000, within the first 4 days of life, we prospectively evaluated HRVi in cocaine-exposed asymptomatic newborns (N = 97) by Holter monitoring. Their data were compared with infants from two control groups (one with no in utero drug exposure, N = 102; the other with exposure to alcohol, nicotine, or marijuana but no cocaine, N = 111). RESULTS: In assessing concordance between and within operators for HRVi, the intraclass correlations were 0.983 (95% CI: 0.958, 0.994) and 0.997 (95% CI: 0.984, 0.999), respectively. Infants with in utero cocaine exposure had significantly (P < 0.0001) lower HRVi than those exposed to other drugs and to no drugs in utero. If abnormal HRVi is defined as < fifth percentile for the no drug exposed group (HRVi < 8), 10% of the cocaine-exposed newborns, in contrast to 2% in each of the control groups (P = 0.003) had abnormal values. CONCLUSION: HRVi is a reliable measure to study heart rate variability in newborns. Asymptomatic infants with in utero cocaine exposure have lower HRVi. Our study supports the clinical use of an abnormal HRVi as a value < 8 for newborn infants.
Sudhir Ken Mehta; Dennis M Super; Ann Salvator; Linda Goetz Fradley; David Connuck; Elizabeth S Kaufman
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  7     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-14     Completed Date:  2003-04-14     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-8     Citation Subset:  IM    
Department of Pediatrics, MetroHealth Campus, Case Western Reserve University, Fairview Hospital, 18101 Lorain Avenue, Cleveland, Ohio 44111-5656, USA.
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MeSH Terms
Birth Weight / drug effects
Body Surface Area
Cocaine / adverse effects,  pharmacology*
Cocaine-Related Disorders
Dopamine Uptake Inhibitors / adverse effects,  pharmacology*
Electrocardiography, Ambulatory
Heart Rate / drug effects*
Infant, Newborn
Pregnancy Complications
Prenatal Exposure Delayed Effects*
Prospective Studies
Reproducibility of Results
Grant Support
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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