| Heart rate variability by triangular index in infants exposed prenatally to cocaine. | |
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MedLine Citation:
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PMID: 12431317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In adults, heart rate variability triangular index (HRVi) is a highly reproducible measure of heart rate variability (HRV), which makes it more suitable for use in longitudinal studies. Although normative data have been published for newborns, studies in infants with pathological conditions are lacking. METHODS: From 1997 to 2000, within the first 4 days of life, we prospectively evaluated HRVi in cocaine-exposed asymptomatic newborns (N = 97) by Holter monitoring. Their data were compared with infants from two control groups (one with no in utero drug exposure, N = 102; the other with exposure to alcohol, nicotine, or marijuana but no cocaine, N = 111). RESULTS: In assessing concordance between and within operators for HRVi, the intraclass correlations were 0.983 (95% CI: 0.958, 0.994) and 0.997 (95% CI: 0.984, 0.999), respectively. Infants with in utero cocaine exposure had significantly (P < 0.0001) lower HRVi than those exposed to other drugs and to no drugs in utero. If abnormal HRVi is defined as < fifth percentile for the no drug exposed group (HRVi < 8), 10% of the cocaine-exposed newborns, in contrast to 2% in each of the control groups (P = 0.003) had abnormal values. CONCLUSION: HRVi is a reliable measure to study heart rate variability in newborns. Asymptomatic infants with in utero cocaine exposure have lower HRVi. Our study supports the clinical use of an abnormal HRVi as a value < 8 for newborn infants. |
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Authors:
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Sudhir Ken Mehta; Dennis M Super; Ann Salvator; Linda Goetz Fradley; David Connuck; Elizabeth S Kaufman |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 7 ISSN: 1082-720X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-14 Completed Date: 2003-04-14 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 374-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, MetroHealth Campus, Case Western Reserve University, Fairview Hospital, 18101 Lorain Avenue, Cleveland, Ohio 44111-5656, USA. ken.mehta@fairviewhospital.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight
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drug effects Body Surface Area Cocaine / adverse effects, pharmacology* Cocaine-Related Disorders Dopamine Uptake Inhibitors / adverse effects, pharmacology* Electrocardiography, Ambulatory Female Heart Rate / drug effects* Humans Infant, Newborn Male Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects* Prospective Studies Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR 00080/RR/NCRR NIH HHS; R01 DA 09049/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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