Document Detail

Heart rate variability before the onset of ventricular tachycardia: differences between slow and fast arrhythmias.
MedLine Citation:
PMID:  12127366     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We tested whether or not heart rate variability (HRV) changes can serve as early signs of ventricular tachycardia (VT) and predict slow and fast VT in patients with an implantable cardioverter defibrillator (ICD). METHODS AND RESULTS: We studied the ICD stored 1000 beat-to-beat intervals before the onset of VT (131 episodes) and during a control time without VT (74 series) in 63 chronic heart failure ICD patients. Standard HRV parameters as well as two nonlinear parameters, namely 'Polvar10' from symbolic dynamics and the finite time growth rates 'Fitgra9' were calculated. Comparing the control and the VT series, no linear HRV parameter showed a significant difference. The nonlinear parameters detected a significant increase in short phases with low variability before the onset of VT (for time series with less than 10% ectopy, P<0.05). Subdividing VT into fast (cycle length <or=270 ms) and slow (>270 ms) events, we found that the onset of slow VT was characterized by a significant increase in heart rate, whereas fast VT was triggered during decreased heart rates, compared to the control series. CONCLUSIONS: Our data may permit the development of automatic ICD algorithms based on nonlinear dynamic HRV parameters to predict VT before it starts. Furthermore, they may facilitate improved prevention strategies.
Udo Meyerfeldt; Niels Wessel; Henry Schütt; Daniela Selbig; Agnes Schumann; Andreas Voss; Jürgen Kurths; Christine Ziehmann; Rainer Dietz; Alexander Schirdewan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  International journal of cardiology     Volume:  84     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2002-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  141-51     Citation Subset:  IM    
HELIOS Klinikum Berlin, Franz-Volhard-Hospital, Charité, Humboldt-University, Wiltbergstrasse 50, D-13125 Berlin, Germany.
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MeSH Terms
Circadian Rhythm / physiology
Defibrillators, Implantable
Follow-Up Studies
Heart Rate / physiology*
Middle Aged
Observer Variation
Tachycardia, Ventricular / physiopathology*,  therapy
Time Factors

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