| Heart rate variability before and after myocardial infarction in conscious dogs at high and low risk of sudden death. | |
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MedLine Citation:
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PMID: 2212380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart rate variability has been demonstrated both experimentally and clinically to be of prognostic importance in determining mortality after myocardial infarction. However, no paired studies have been reported to examine heart rate variability before and after myocardial infarction. The hypothesis was tested that low values of heart rate variability provided risk assessment both before and after myocardial infarction with use of an established canine model of sudden cardiac death. Risk for sudden death was assessed 1 month after myocardial infarction by a protocol in which exercise and myocardial ischemia were combined; dogs that developed ventricular fibrillation were classified at high risk for sudden death (susceptible) and the survivors were considered low risk (resistant). In resistant dogs, myocardial infarction did not affect any measure of heart rate variability: 1) mean RR interval, 2) standard deviation of the mean RR interval, and 3) the coefficient of variance (standard deviation/RR interval). By contrast, after myocardial infarction, susceptible dogs showed significant decrease in all measures of heart rate variability. Before myocardial infarction, no differences were seen between susceptible and resistant dogs. However, 30 days after infarction, epidemiologic analysis of the coefficient of variance showed high sensitivity and specificity (88% and 80%, respectively), predicting susceptibility. Therefore, results of analysis of 30 min of beat to beat heart period at rest 30 days after myocardial infarction are highly predictive for increased risk of sudden death. |
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Authors:
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S S Hull; A R Evans; E Vanoli; P B Adamson; M Stramba-Badiale; D E Albert; R D Foreman; P J Schwartz |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 16 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-11-21 Completed Date: 1990-11-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 978-85 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology and Biophysics, Oklahoma University Health Sciences Center, Oklahoma City 73190. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Death, Sudden / epidemiology* Disease Models, Animal Dogs Electrocardiography Heart Rate / physiology* Male Myocardial Infarction / mortality, physiopathology* Physical Exertion Prognosis Risk Factors Ventricular Fibrillation / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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HL33727/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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