Document Detail


Heart rate variability and baroreflex function in AT2 receptor-disrupted mice.
MedLine Citation:
PMID:  12154115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We adapted telemetry and sequence analysis employed in humans to mice and measured heart rate variability and the spontaneous baroreflex sensitivity in angiotensin II type 2 (AT2) receptor-deleted (AT2 -/-) and wild-type (AT2 +/+) mice with either deoxycorticosterone acetate (DOCA)-salt hypertension or N(omega)-nitro-L-arginine methylester hydrochloride (L-NAME) hypertension. Mean arterial pressure leveled during the day at 101+/-1 mm Hg and during the night at 109+/-1 mm Hg in AT2 receptor-deleted mice, compared with 98+/-2 mm Hg (day) and 104+/-2 mm Hg (night) in wild-type mice. Mean arterial pressure increased in AT2 receptor-deleted mice with L-NAME to 114+/-1 mm Hg (day) and 121+/-1 mm Hg (night), compared with 105+/-2 mm Hg (day) and 111+/-2 mm Hg (night), respectively. DOCA-salt also increased day and night blood pressures in AT2 receptor-deleted mice to a greater degree than in wild-type mice. Heart rate variability in the time and frequency domain was not different between AT2 receptor-deleted mice and AT2 receptor-deleted mice at baseline. Systolic blood pressure variability in the low frequency band was lower in AT2 receptor-deleted mice (0.6+/-0.1 ms2 versus 3.9+/-1.3 ms2) than in wild-type mice. Baroreceptor-heart rate reflex sensitivity was significantly increased in AT2 receptor-deleted mice compared with wild-type mice (3.4+/-0.6 versus 2.1+/-0.5 ms/mm Hg). These differences remained after DOCA-salt and L-NAME treatments. We conclude that activation of the AT2 receptor impairs arterial baroreceptor reflex function, probably by a central action. These data support the existence of an inhibitory central effect of the AT2 receptor on baroreflex function.
Authors:
Volkmar Gross; Ralph Plehm; Jens Tank; Jens Jordan; Andre Diedrich; Michael Obst; Friedrich C Luft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  40     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-02     Completed Date:  2002-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
Affiliation:
Max-Delbrück-Center for Molecular Medicine, Helios-Klinikum-Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Baroreflex / genetics,  physiology*
Blood Pressure / drug effects,  genetics,  physiology
Desoxycorticosterone / pharmacology
Genotype
Heart Rate / drug effects,  genetics,  physiology*
Mice
Mice, Knockout
NG-Nitroarginine Methyl Ester / pharmacology
Receptor, Angiotensin, Type 2
Receptors, Angiotensin / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Receptor, Angiotensin, Type 2; 0/Receptors, Angiotensin; 50903-99-6/NG-Nitroarginine Methyl Ester; 64-85-7/Desoxycorticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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