| Heart rate variability as a means of assessing prognosis after acute myocardial infarction. A 3-year follow-up study. | |
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MedLine Citation:
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PMID: 9152649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The present study evaluated the prognostic value of heart rate variability after acute myocardial infarction in comparison with other known risk factors. The cut-off points that maximized the hazards ratio were also explored. PATIENTS AND METHODS: Heart rate variability was assessed with 24 h ambulatory electrocardiography in 74 patients with acute myocardial infarction, 4 +/- 2 days after hospital admission and in 24 healthy controls. Patients were followed for 36 +/- 15 months. RESULTS: During follow-up, 18 patients died, nine suffered a non-fatal infarction and 20 underwent revascularization procedures. Heart rate variability was higher in survivors than in non-survivors (P = 0.005). This difference was found at higher statistical levels when comparing non-survivors vs controls (P = 0.0002). A similar statistically significant difference was also found between survivors vs controls (P = 0.04). Patients suffering non-fatal infarction and cardiac events (defined as death, non-fatal infarction or revascularization) had a lower heart rate variability than those without (P = 0.03 and P = 0.03, respectively). With multivariate regression analysis, decreased heart rate variability independently predicted mortality and death or non-fatal infarction. The presence of a left ventricular ejection fraction < 40% and a history of systemic hypertension were, however, stronger predictors. The cut-off points that maximized the hazards ratio using the Cox model differed from those reported by others. CONCLUSION: Decreased heart rate variability independently predicted poor prognosis after myocardial infarction. However, the cut-off points that should be used in clinical practice are still a matter for further investigation. |
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Authors:
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M Quintana; N Storck; L E Lindblad; K Lindvall; M Ericson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 18 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-25 Completed Date: 1997-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 789-97 Citation Subset: IM |
Affiliation:
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Karolinska Institute, Department of Cardiology, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiovascular Agents / therapeutic use Electrocardiography, Ambulatory / statistics & numerical data* Female Follow-Up Studies Heart Rate / drug effects, physiology* Humans Male Middle Aged Myocardial Infarction / drug therapy, mortality*, physiopathology Proportional Hazards Models Risk Factors Sensitivity and Specificity Signal Processing, Computer-Assisted Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 1997 May;18(5):710-2
[PMID:
9152638
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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