| Heart rate variability analysis allows early asphyxia detection in ovine fetus. | |
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MedLine Citation:
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PMID: 19164481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fetal heart rate (FHR) monitoring is commonly used to predict asphyxia but clinical and experimental studies have questioned its diagnostic value. We examined the usefulness of fetal heart rate variability (fHRV) measures in detecting early asphyxia using chronically instrumented fetal sheep under normoxic (n = 6) and asphyxic conditions (3 umbilical cord occlusions, n = 6). The occlusions consistently led to pH decreases from 7.35 +/- 0.01 to 7.09 +/- 0.03 ( P < .05). FHR showed biphasic deceleration during each occlusion, associated with increasing arterial blood pressure ( P < .05). RMSSD, an index of vagal modulation of fHRV, increased consistently during repeated occlusion induced FHR decelerations ( P < .05). Under normoxic conditions, RMSSD did not change during FHR decelerations and decreased during FHR accelerations ( P < .05). Our results suggest that an increase of RMSSD in association with FHR decelerations reflects initial vagal activation during fetal asphyxia. RMSSD may accurately identify asphyxic fetuses early. Clinical validation is needed. |
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Authors:
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Martin G Frasch; Thomas Müller; Christian Weiss; Karin Schwab; Harald Schubert; Matthias Schwab |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-22 |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 16 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-13 Completed Date: 2009-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 509-17 Citation Subset: IM |
Affiliation:
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Department of Neurology, Friedrich Schiller University, D-07740 Jena, Germany. mfrasch@uwo.ca. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asphyxia / diagnosis*, physiopathology* Early Diagnosis Female Heart Rate / physiology Heart Rate, Fetal / physiology* Pregnancy Prenatal Diagnosis / methods Sheep, Domestic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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