Document Detail

Heart rate turbulence slope reduction in imminent ventricular tachyarrhythmia and its implications.
MedLine Citation:
PMID:  16836669     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The aim of this study was to see whether heart rate turbulence (HRT) parameters change preceding imminent ventricular tachyarrhythmias (VT/VF). METHODS AND RESULTS: The Spontaneous Ventricular Tachyarrhythmia Database (Medtronic Version 1.0) consisting of 83 paired (control and pre-VT/VF) sets of 1,000 RR intervals recorded by the Medtronic Jewel Plus ICD was used. Sixty-one control records and 69 pre-VT/VF records had two or more ectopic beats, allowing calculation of six HRT indices: means and standard deviations (SD) of turbulence slope (TS), turbulence onset (TO), and turbulence timing (TT). The only index found to be different between control and pre-VT/VF records was SD of TS (4.2 +/- 3.0 control vs 3.1 +/- 1.9 pre-VT/VF, P < 0.05). Thirty-one datasets classified as having normal HRT in control demonstrated a decrease of both TS mean (P < 0.01) and SD (P < 0.01), and loss of correlation between TS mean and left ventricular ejection fraction (LVEF) preceding VT/VF (P < 0.0001 control, P = 0.8 pre-VT/VF). CONCLUSION: Both mean and SD of TS are reduced before VT/VF, but only in patients who have normal baseline HRT, and are capable of manifesting reduction. This may be why previous studies could not agree on pre-arrhythmia characteristics.
Mari A Watanabe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  17     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-13     Completed Date:  2006-11-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  735-40     Citation Subset:  IM    
Internal Medicine Department, Munich University of Technology, Munich, Germany.
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MeSH Terms
Biophysical Phenomena
Defibrillators, Implantable
Heart Rate*
Middle Aged
Tachycardia, Ventricular / physiopathology*,  therapy
Grant Support
2T32 HL07374-19/HL/NHLBI NIH HHS

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