Document Detail

Heart rate turbulence assessment in systemic sclerosis: the role for the detection of cardiac autonomic nervous system dysfunction.
MedLine Citation:
PMID:  20007288     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the heart rate turbulence (HRT) in patients with SSc as a method of assessment for cardiac autonomic nervous function.
METHODS: We prospectively studied 68 consecutive patients with SSc before inclusion in the study. After a detailed clinical evaluation, including echocardiography, 45 subjects [aged 54.6 (14.7) years; 40 women] underwent 24-h Holter monitoring for HRT and time- and frequency-domain heart rate variability (HRV) assessment. Results were compared with those in 30 age- and sex-matched healthy controls.
RESULTS: As compared with controls, HRT was impaired in SSc patients: the median turbulence onset (TO) was higher (P = 0.0001) and the median turbulence slope (TS) was lower (P = 0.0003). Abnormal HRT (TO > or =0.0% and/or TS < or =2.5 ms/RR) was found in 42% of SSc patients. Moreover, SSc duration correlated negatively with values of TS (r = -0.3; P = 0.045). HRT did not differ between diffuse and limited SSc groups. All estimated time- and the majority of frequency-domain values of HRV parameters in SSc were significantly lower than in controls. Significant correlations were also demonstrated between HRT and HRV parameters.
CONCLUSIONS: HRT, like HRV assessment, indicates a frequent impairment of the cardiac autonomic nervous system in SSc patients, irrespective of the SSc type.
Piotr Bienias; Michal Ciurzyński; Maria Glińska-Wielochowska; Agnieszka Szewczyk; Dariusz Korczak; Agnieszka Kalińska-Bienias; Wieslaw Gliński; Piotr Pruszczyk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-09
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  49     ISSN:  1462-0332     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-14     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  355-60     Citation Subset:  AIM; IM    
Department of Internal Medicine and Cardiology, Medical University of Warsaw, 02-005 Warsaw, Lindleya 4, Poland.
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MeSH Terms
Arrhythmias, Cardiac / diagnosis,  etiology*,  physiopathology
Autonomic Nervous System Diseases / diagnosis,  etiology*,  physiopathology
Case-Control Studies
Electrocardiography, Ambulatory / methods
Heart / innervation
Heart Rate / physiology
Middle Aged
Prospective Studies
Scleroderma, Systemic / complications*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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