Document Detail

Heart rate responsiveness after sustained chronotropic stimulation with a beta 1-adrenergic receptor agonist.
MedLine Citation:
PMID:  6854129     Owner:  NLM     Status:  MEDLINE    
Six normal male human subjects underwent two 72 hr infusions of saline (control) and butopamine, a beta-adrenergic agonist with strong positive chronotropic properties, in order to determine the chronotropic responsiveness of the human heart after sustained chronotropic stimulation. Chronotropic responsiveness was assessed by heart rate responses to intravenous isoproterenol and bicycle ergometry before and serially over 50 hr after discontinuation of the infusions. Chronotropic responsiveness to isoproterenol and exercise was reduced significantly in the butopamine group compared to control; this blunted chronotropic effect persisted beyond 48 hr. Positive inotropic responsiveness, assessed by echocardiography and systolic time intervals, was reduced modestly for the butopamine-treated group up to 24 hr after infusion. Although the precise mechanisms are not fully elucidated, continuous chronotropic stimulation of the human heart with the beta 1 agonist, butopamine, elicits a significant reduction in the heart rate response to isoproterenol and exercise challenges. In addition, the degree and time course of suppression of the chronotropic vs. inotropic responsiveness are disparate.
C V Leier; S Nelson; R D Magorien; H Boudoulas; L Gibb; D V Unverferth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  101     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  955-63     Citation Subset:  AIM; IM    
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MeSH Terms
2-Hydroxyphenethylamine / analogs & derivatives,  pharmacology*
Blood Pressure / drug effects
Cardiotonic Agents / pharmacology*
Heart Rate / drug effects*
Isoproterenol / pharmacology
Phenethylamines / pharmacology*
Physical Exertion
Grant Support
Reg. No./Substance:
0/Cardiotonic Agents; 0/Phenethylamines; 66734-12-1/butopamine; 7568-93-6/2-Hydroxyphenethylamine; 7683-59-2/Isoproterenol

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