| Heart rate response to graded exercise correlates with aerobic and ventilatory capacity in patients with heart failure. | |
| | |
MedLine Citation:
|
PMID: 15704528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Autonomic dysfunction and reduced exercise tolerance are typical features of patients with congestive heart failure (CHF). Baro-chemoreflex balance and organ response may have a common role in conditioning exercise tolerance, ventilation, and chronotropic competence in patients with CHF. HYPOTHESIS: We tested the hypothesis that there is a relationship between functional capacity and chronotropic competence to exercise in CHF. METHODS: In all, 48 stable outpatients with CHF (age 65 +/- 10 years, 41 men, NYHA class 2.1 +/- 0, ejection fraction 31 +/- 7%, peak VO2 16 +/- 4 ml/kg/min) performed cardiopulmonary exercise testing (CPX). Heart rate (HR) response to exercise was assessed by the chronotropic index (CRI). The CRI was calculated by the following formula: CRI = peak HR - rest HR/220 - age - rest HR x 100 (normal value > 80%). The relationship of CRI to peak oxygen consumption (VO2) and ventilation/carbon dioxide production (VE/VCO2) ratio was examined. A group of 33 healthy controls underwent CPX as well. RESULTS: The CRI correlated directly with peak VO2 (r = 0.638, p < 0.001) and inversely with VE/VCO2 (r = -0.492, p < 0.001) in patients with CHF. A CRI < 78% identified patients with CHF and a peak VO2 < 20 ml/kg/min, area under the receiver operating curve (AUROC): 0.76, 95% confidence interval (CI) 0.60-0.92. A CRI < 74% predicted exercise hyperventilation in CHF (AUROC: 0.71 for VE/VCO2 > 30, 95% CI 0.53-0.88). The CRI was not significantly related either to peak VO2 or to VE/VCO2 in the control group. CONCLUSIONS: In patients with mild to moderate CHF, CRI correlates with functional capacity. This relationship adds new data on pathophysiologic grounds and supports the routine incorporation of CRI into CPX interpretation. |
| | |
Authors:
|
Alessandro Vallebona; Guido Gigli; Sandro Orlandi; Giorgio Reggiardo |
Related Documents
:
|
8604638 - Physical deconditioning may be a mechanism for the skeletal muscle energy phosphate met... 16158008 - Exercise duration and peak systolic blood pressure are predictive of mortality in ambul... 11409228 - A comparison of ambulatory oxygen consumption during circuit training and aerobic exerc... 8896738 - Ventilation during exercise in chronic heart failure. 10092568 - Effect of repetitive episodes of exercise induced myocardial ischaemia on left ventricu... 20029508 - Trunk muscle activation during moderate- and high-intensity running. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical cardiology Volume: 28 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2005-02-11 Completed Date: 2005-05-17 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 25-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Heart Failure Unit, Rapallo Hospital, Rapallo (Genoa), Italy. avallebona@as14.liguria.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Case-Control Studies Exercise / physiology* Exercise Tolerance / physiology* Female Heart Failure / physiopathology* Heart Rate / physiology* Humans Lung Volume Measurements Male Middle Aged Oxygen Consumption / physiology* Pulmonary Ventilation / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The imbalance between coronary reserve and wall stress explains the severity of ventricular dysfunct...
Next Document: Monocyte chemoattractant protein-1 and recurrent cardiovascular events in patients with stable coron...