| Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling. | |
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MedLine Citation:
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PMID: 20952661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the effect of chronic heart rate (HR) reduction with the hyperpolarization-activated current inhibitor ivabradine on the global phenotype of left ventricular (LV) remodeling in a ligated rat model. Seven days after coronary artery ligation, Wistar rats received ivabradine (10 mg · kg(-1) · day(-1) administered in drinking water) [myocardial infarction + ivabradine (MI+IVA), n = 22] or vehicle only (drinking water) (MI, n = 20) for 90 days. A sham group (n = 20) was included for model validation. MI+IVA rats had 12% lower HR (P < 0.01), improved LV volumes, 15% higher LV ejection fraction (LVEF, P < 0.01) than MI rats, and 33% reductions in both plasma atrial natriuretic peptide (ANP, P = 0.052) and cardiac hydroxyproline. Using patch-clamp, action potential duration was reduced and transient outward current density increased (P < 0.05). Cardiac energy metabolism was also improved (+33% creatine phosphate, P < 0.001; +15% ATP; and +9% energy charge, P < 0.05). Significant correlations were found between HR and parameters of cardiac metabolism, ANP, and LVEF (all P < 0.05). The HR-reducing properties of ivabradine prevent changes in the global phenotype of LV remodeling in the rat, optimize energy consumption, and avoid electrophysiological and structural remodeling. |
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Authors:
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Claudio Ceconi; Laura Comini; Silvia Suffredini; Francesca Stillitano; Muriel Bouly; Elisabetta Cerbai; Alessandro Mugelli; Roberto Ferrari |
Publication Detail:
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Type: Journal Article Date: 2010-10-15 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 300 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-04 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H366-73 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Ferrara, Ferrara, Italy. claudio.ceconi@unife.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects,
physiology Animals Benzazepines / pharmacology* Electrocardiography Energy Metabolism / drug effects, physiology Heart / drug effects*, physiopathology Heart Rate / drug effects*, physiology Male Myocardial Infarction / metabolism, physiopathology Myocardium / metabolism Rats Rats, Wistar Ventricular Function, Left / drug effects*, physiology Ventricular Remodeling / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 155974-00-8/ivabradine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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