Document Detail


Heart-rate recovery index is impaired in Behçet's disease.
MedLine Citation:
PMID:  19693299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behçet's disease, a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. Heart-rate recovery after exercise can provide both an estimate of impaired parasympathetic tone and a prognosis in regard to all-cause and cardiovascular death. The aim of our study was to evaluate heart-rate recovery in Behçet's disease. From January through July 2008, we examined at our outpatient clinic and prospectively enrolled 30 consecutive patients with Behçet's disease and 50 healthy control participants who were matched for age and sex. Basal electrocardiography, echocardiography, and treadmill exercise testing were performed in all patients and control participants. The heart-rate recovery index was calculated in the usual manner, by subtracting the 1st-minute (Rec1), 2nd-minute (Rec2), and 3rd-minute (Rec3) recovery heart rates from the maximal heart rate after exercise stress testing. Patients with Behçet's disease exhibited significantly lower heart-rate recovery numbers, compared with healthy control participants: Rec1, 24.28 +/- 8.2 vs 34.4 +/- 7.6, P = 0.002; Rec2, 49.28 +/- 11.2 vs 57.5 +/- 7.0, P < 0.05; and Rec3, 56.2 +/- 12.11 vs 67.4 +/- 8.7, P = 0.014. To our knowledge, this is the 1st study that shows an impaired heart-rate recovery index (indicative of reduced parasympathetic activity) among patients with Behçet's disease. Given the independent prognostic value of the heart-rate recovery index, our results may explain the increased occurrence of arrhythmias and sudden cardiac death in Behçet's patients. Therefore, this index may be clinically useful in the identification of high-risk patients.
Authors:
Ergun Baris Kaya; Hikmet Yorgun; Ali Akdogan; Ahmet Hakan Ates; Ugur Canpolat; Hamza Sunman; Kudret Aytemir; Lale Tokgozoglu; Giray Kabakci; Meral Calguneri; Hilmi Ozkutlu; Ali Oto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  36     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-10-29     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-6     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Hacettepe University Faculty of Medicine, Altindag 06100, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Behcet Syndrome / complications,  diagnosis,  physiopathology*
Cardiovascular Diseases / etiology*,  physiopathology
Case-Control Studies
Echocardiography
Electrocardiography
Exercise Test
Female
Heart Rate*
Humans
Male
Middle Aged
Parasympathetic Nervous System / physiopathology
Predictive Value of Tests
Prognosis
Prospective Studies
Recovery of Function
Risk Assessment
Time Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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