| Heart rate periodicities during induction of propofol-nitrous oxide-isoflurane anaesthesia. | |
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MedLine Citation:
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PMID: 1642913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the variation in cardiac inter-beat interval during induction of anaesthesia with propofol and subsequent inhalation anaesthesia with nitrous oxide and isoflurane. In comparison with preoperative control values, heart rate variability was reduced by anaesthesia and there was a complex, but consistent, pattern of R-R interval change during induction. Immediately after propofol 2 mg kg-1, high frequency heart rate oscillations were replaced by low frequency oscillations (0.05 Hz). Subsequently, with decreasing propofol and deepening nitrous oxide-isoflurane anaesthesia, high frequency components returned towards, although not reaching, control values; low and, to a greater extent, mid range (0.1-Hz) frequency components remained reduced. We postulate that these alterations are consistent with an immediate but transient post-induction ventilatory depression, subsequent decrease in efferent sympathetic activity and reduction in baroreflex responsiveness. R-R interval analysis is suggested to be a useful tool in the evaluation of autonomic function during anaesthesia. |
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Authors:
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D C Galletly; T Corfiatis; A M Westenberg; B J Robinson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of anaesthesia Volume: 68 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-09-09 Completed Date: 1992-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 360-4 Citation Subset: IM |
Affiliation:
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Section of Anaesthesia, Wellington School of Medicine, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anesthesia, General* Anesthesia, Inhalation* Female Heart Rate / drug effects* Humans Isoflurane Male Nitrous Oxide Propofol Time Factors |
| Chemical | |
Reg. No./Substance:
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10024-97-2/Nitrous Oxide; 2078-54-8/Propofol; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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