Document Detail


Heart rate per se impacts cardiac function in patients with systolic heart failure and pacing: a pilot study.
MedLine Citation:
PMID:  19147457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: This study was designed to compare the specific effects of two heart rates (HR), 55 and 75 b.p.m., in patients with heart failure (HF).
METHODS AND RESULTS: Patients with chronic HF, left ventricular ejection fraction (LVEF) </= 35%, and a pacemaker with >90% of paced QRS, were included in a randomized cross-over trial of two 3-month periods where pacing rate was set at either 55 or 75 b.p.m. At the end of each period, patients were examined and radionuclide ventriculography, echocardiography, and blood sampling were performed for centralized and blinded analysis. Two patients did not complete the study because of early worsening while paced at 75 b.p.m. Twelve patients completed the study. Compared with 75 b.p.m., pacing at 55 b.p.m. was associated with a higher LVEF [+4.7% (2.6-6.7), P < 0.001], lower B-type natriuretic peptide levels [-91 pg/mL (-148 to -33), P < 0.01], lower systolic pulmonary artery pressure (41 +/- 10 vs. 47 +/- 10 mmHg, P = 0.02) and lower NYHA (New York Heart Association) class (2.2 +/- 0.6 vs. 2.6 +/- 0.5, P = 0.03). The baseline pacing rate prior to inclusion had no effect on results.
CONCLUSION: HR per se may impact cardiac function and low HR might be beneficial in patients with systolic HF compared with intermediate HR.
Authors:
Damien Logeart; Jean-Pierre Gueffet; François Rouzet; Françoise Pousset; Christophe Chavelas; Alain Cohen Solal; Guillaume Jondeau
Related Documents :
3598457 - Electrocardiographically discrete right and left ventricular qrs complexes: a case report.
12893637 - Synchronization of ventricular fibrillation with real-time feedback pacing: implication...
3348257 - Termination of ventricular tachycardia by chest wall stimulation during ddd pacing. a r...
16039257 - Minimally invasive surgical alternatives for left ventricle epicardial lead implantatio...
17767537 - Demonstration of left ventricular outflow tract eccentricity by real time 3d echocardio...
2389687 - Evidence for a role of platelet activating factor in the pathogenesis of irreversible b...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of heart failure     Volume:  11     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-03-19     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
Affiliation:
Hôpital Lariboisière, Cardiology Department, Assistance Publique - Hôpitaux de Paris, Paris, France. damien.logeart@lrb.aphp.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Cardiac Pacing, Artificial
Chronic Disease
Cross-Over Studies
Female
Heart Failure, Systolic / diagnosis,  physiopathology*,  therapy
Heart Rate / physiology*
Humans
Male
Middle Aged
Natriuretic Peptide, Brain / blood
Pilot Projects
Radionuclide Ventriculography
Stroke Volume
Ventricular Function, Left / physiology
Chemical
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The clinical utility of brain natriuretic peptide in paediatric left ventricular failure.
Next Document:  Effects of global longitudinal strain and total scar burden on response to cardiac resynchronization...