Document Detail

Heart rate per se impacts cardiac function in patients with systolic heart failure and pacing: a pilot study.
MedLine Citation:
PMID:  19147457     Owner:  NLM     Status:  MEDLINE    
AIMS: This study was designed to compare the specific effects of two heart rates (HR), 55 and 75 b.p.m., in patients with heart failure (HF).
METHODS AND RESULTS: Patients with chronic HF, left ventricular ejection fraction (LVEF) </= 35%, and a pacemaker with >90% of paced QRS, were included in a randomized cross-over trial of two 3-month periods where pacing rate was set at either 55 or 75 b.p.m. At the end of each period, patients were examined and radionuclide ventriculography, echocardiography, and blood sampling were performed for centralized and blinded analysis. Two patients did not complete the study because of early worsening while paced at 75 b.p.m. Twelve patients completed the study. Compared with 75 b.p.m., pacing at 55 b.p.m. was associated with a higher LVEF [+4.7% (2.6-6.7), P < 0.001], lower B-type natriuretic peptide levels [-91 pg/mL (-148 to -33), P < 0.01], lower systolic pulmonary artery pressure (41 +/- 10 vs. 47 +/- 10 mmHg, P = 0.02) and lower NYHA (New York Heart Association) class (2.2 +/- 0.6 vs. 2.6 +/- 0.5, P = 0.03). The baseline pacing rate prior to inclusion had no effect on results.
CONCLUSION: HR per se may impact cardiac function and low HR might be beneficial in patients with systolic HF compared with intermediate HR.
Damien Logeart; Jean-Pierre Gueffet; François Rouzet; Françoise Pousset; Christophe Chavelas; Alain Cohen Solal; Guillaume Jondeau
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of heart failure     Volume:  11     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-03-19     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
Hôpital Lariboisière, Cardiology Department, Assistance Publique - Hôpitaux de Paris, Paris, France.
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MeSH Terms
Cardiac Pacing, Artificial
Chronic Disease
Cross-Over Studies
Heart Failure, Systolic / diagnosis,  physiopathology*,  therapy
Heart Rate / physiology*
Middle Aged
Natriuretic Peptide, Brain / blood
Pilot Projects
Radionuclide Ventriculography
Stroke Volume
Ventricular Function, Left / physiology
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

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