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Heart rate-mediated blood pressure control in preterm fetal sheep under normal and hypoxic-ischemic conditions.
MedLine Citation:
PMID:  23340656     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:The understanding of hypoxemia-induced changes in baroreflex function is limited and may be studied in a fetal sheep experiment before, during, and after standardized hypoxic conditions.Methods:Preterm fetal lambs were instrumented at 102 days gestation (term: 146 days). At 106 days intra-uterine hypoxic-ischemia was induced by 25-min of umbilical cord occlusion (UCO). Baroreflex related fluctuations were calculated at 30-min intervals during the first week after UCO by transfer function (cross-spectral) analysis between systolic blood pressure and R-R interval fluctuations, estimated in the low frequency (LF, 0.04-0.15 Hz) band. LF transfer gain (baroreflex sensitivity) and delay (s) reflect the baroreflex function.Results:Baseline showed no differences in LF transfer gain and delay between controls and UCO. In controls, LF gain showed postnatal increase. In contrast, LF gain gradually decreased in the UCO group, resulting in significantly lower values 4-7 days after UCO. In the UCO group, LF delay increased and differed significantly from controls.Conclusions:Our results show that intra-uterine hypoxic-ischemia results in reduced baroreflex sensitivity over a period of 7 days, indicating limited efficacy to buffer blood pressure changes by adapting heart rate. Cardiovascular dysregulation may augment already present cerebral damage after systemic hypoxic-ischemia in the reperfusion period.Pediatric Research (2013); doi:10.1038/pr.2013.15.
Authors:
Alex Zwanenburg; Reint K Jellema; Ward Jennekens; Daan Ophelders; Rik Vullings; Arne van Hunnik; Carola van Pul; Laura Bennet; Tammo Delhaas; Boris W Kramer; Peter Andriessen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Neonatal Intensive Care Unit, Máxima Medical Centre, Veldhoven, The Netherlands [2] Department of Clinical Physics, Máxima Medical Centre, Veldhoven, The Netherlands [3] Department of BioMedical Engineering, Maastricht University, Maastricht, The Netherlands [4] CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.
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