| Heart rate independence of catecholamine-induced myocardial damage in the newborn pig. | |
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MedLine Citation:
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PMID: 7936836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonates undergoing heart surgery are exposed to high levels of circulating catecholamines. Our objective was to determine to what extent epinephrine (E)-related cardiotoxicity can be attributed to induced tachycardia. We assessed left ventricle function by pressure-volume data obtained by conductance catheter/micromanometer technique and correlated it with ultrastructure in newborn piglets (3 to 7 d old). Group A (n = 6) received E (1 microgram/kg/min) for 2 h, whereas group B piglets (n = 6) were atrially paced at a rate (220/min) matched to group A. Left ventricle peak systolic pressure and stroke work were significantly higher (p < 0.05) in group A. End-systolic elastance increased during E infusion (70%) versus no significant change in group B. After 2 h of E infusion, end-systolic elastance was significantly reduced in group A from 9.8 +/- 3.5 to 5 +/- 2.4 mm Hg/mL (p < 0.05). Chamber stiffness index increased during E infusion from 0.36 +/- 0.2 to 0.6 +/- 0.3 mL-1 (p < 0.05) and remained elevated (0.58 +/- 0.2 mL-1) after E infusion was discontinued versus no change in group B. E-induced left ventricle dysfunction was associated with scattered but irreversible ultrastructural changes consisting of sarcolemmal rupture and loss of mitochondrial architecture, whereas only minor reversible changes such as microvesicular lipid accumulation and mitochondrial swelling were seen in group B. We conclude that E cardiotoxicity in the neonate is independent of induced tachycardia. |
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Authors:
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J Caspi; J G Coles; L N Benson; S L Herman; J A Act; G J Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 36 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-11-22 Completed Date: 1994-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 49-54 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Surgery, Hospital For Sick Children, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Animals, Newborn Blood Pressure / drug effects Cardiac Pacing, Artificial Cardiomyopathies / chemically induced, physiopathology* Epinephrine / blood, toxicity* Heart Rate / drug effects* Microscopy, Electron Norepinephrine / blood Swine Ventricular Function, Left / physiology |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine; 56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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