| Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans. | |
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MedLine Citation:
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PMID: 10066689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Feed-forward and feedback mechanisms are both important for control of the heart rate response to muscular exercise, but their origin and relative importance remain inadequately understood. To evaluate whether humoral mechanisms are of importance, the heart rate response to electrically induced cycling was studied in participants with spinal cord injury (SCI) and compared with that elicited during volitional cycling in able-bodied persons (C). During voluntary exercise at an oxygen uptake of approximately 1 l/min, heart rate increased from 66 +/- 4 to 86 +/- 4 (SE) beats/min in seven C, and during electrically induced exercise at a similar oxygen uptake in SCI it increased from 73 +/- 3 to 110 +/- 8 beats/min. In contrast, blood pressure increased only in C (from 88 +/- 3 to 99 +/- 4 mmHg), confirming that, during exercise, blood pressure control is dominated by peripheral neural feedback mechanisms. With vascular occlusion of the legs, the exercise-induced increase in heart rate was reduced or even eliminated in the electrically stimulated SCI. For C, heart rate tended to be lower than during exercise with free circulation to the legs. Release of the cuff elevated heart rate only in SCI. These data suggest that humoral feedback is of importance for the heart rate response to exercise and especially so when influence from the central nervous system and peripheral neural feedback from the working muscles are impaired or eliminated during electrically induced exercise in individuals with SCI. |
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Authors:
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M Kjaer; F Pott; T Mohr; P Linkis; P Tornøe; N H Secher |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 86 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-05-07 Completed Date: 1999-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 806-11 Citation Subset: IM |
Affiliation:
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Sports Medicine Research Unit, Department of Rheumatology H, Bispebjerg Hospital, DK-2400 Copenhagen NV. mlkjaer@mfi.ku.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bicycling Blood Pressure / physiology Electric Stimulation Exercise / physiology* Female Heart Rate / physiology* Humans Ischemia / physiopathology* Leg / blood supply*, physiology* Male Paraplegia / physiopathology Quadriplegia / physiopathology Regional Blood Flow / physiology Respiratory Mechanics / physiology Rest / physiology Spinal Cord Injuries / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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