| Heart rate-corrected QT interval and QT dispersion in patients with pulmonary hypertension. | |
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MedLine Citation:
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PMID: 19562296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Heart rate-corrected QT interval (QTc) and QTc dispersion (QTcd) are increased and associated with ventricular arrhythmia and an increase in sudden death in a variety of diseases. This study aimed to examine QTc and QTcd in pulmonary hypertension and assess their relationship with pulmonary arterial pressure. PATIENTS AND METHODS: A total of 201 patients who had undergone right heart catheterization for a preliminary diagnosis of pulmonary hypertension between December 2003 and July 2008 were included in the study. Resting 12-lead electrocardiogram was recorded. QT interval was measured manually and corrected using Bazett's formula. Patients were divided into groups with mild-to-moderate and severe pulmonary hypertension and a control group according to mean pulmonary arterial pressure. RESULTS: In all observed cases, mean QTc was higher in severe pulmonary hypertension than in controls (428.6 +/- 32.8 ms vs. 411.1 +/- 28.4 ms, P = 0.018) and QTcd was higher in mild-to-moderate (60.1 +/- 17.2 ms) and severe pulmonary hypertension (63.9 +/- 20.5 ms) than in controls (47.3 +/- 10.6 ms) (P = 0.031; P = 0.004). In men, there was no significant difference in mean QTc and QTcd. In women, mean QTc was higher in severe pulmonary hypertension than in controls (436.1 +/- 39.4 ms vs. 407.6 +/- 24.8 ms, P = 0.037) and QTcd was higher in severe pulmonary hypertension (68.5 +/- 20.9 ms) than in both the controls (45.1 +/- 12.6 ms) and patients with mild-to-moderate pulmonary hypertension (58.6 +/- 14.7 ms) (P = 0.002; P = 0.003). In addition, in women with pulmonary hypertension, mean QTc and QTcd were positively correlated to mean pulmonary arterial pressure (r = 0.207, P = 0.03; r = 0.236, P = 0.012). CONCLUSIONS: In women with pulmonary hypertension, mean QTc and QTcd are positively correlated to mean pulmonary arterial pressure and are significantly increased in patients with severe pulmonary hypertension. |
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Authors:
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Zhang Hong-liang; Luo Qin; Liu Zhi-hong; Zhao Zhi-hui; Xiong Chang-ming; Ni Xin-hai; He Jian-guo; Wei Ying-jie; Zhang Shu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Wiener klinische Wochenschrift Volume: 121 ISSN: 0043-5325 ISO Abbreviation: Wien. Klin. Wochenschr. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-29 Completed Date: 2009-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 21620870R Medline TA: Wien Klin Wochenschr Country: Austria |
Other Details:
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Languages: eng Pagination: 330-3 Citation Subset: IM |
Affiliation:
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Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Body Mass Index China Death, Sudden, Cardiac / etiology Electrocardiography* Female Heart Rate / physiology* Humans Hypertension, Pulmonary / diagnosis, physiopathology* Long QT Syndrome / diagnosis, physiopathology* Male Middle Aged Pulmonary Wedge Pressure / physiology Risk Factors Sex Factors Signal Processing, Computer-Assisted* Tachycardia, Ventricular / diagnosis, physiopathology |
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