Document Detail

Heart rate and blood pressure variability effects as a result of oxygen and nitrous oxide administration in the anesthetized mouse.
MedLine Citation:
PMID:  21096438     Owner:  NLM     Status:  MEDLINE    
This study examines the effects of changing oxygen fractional inspiration ratio (FiO(2)), and nitrous oxide (N(2)O) for the improvement of cardiovascular control of mean arterial blood pressure (MAP) and heart rate (HR) in C57BL/6 mice under isoflurane anesthesia (1.5%) for up to 90 minutes post-induction. Heart rate variability (HRV) indices are also quantified under these conditions. The results indicate that changing the FiO(2) does result in lower MAP and HR values compared to the case of N(2)O (50%) administration to the isoflurane gas mixture. HRV indices declined over the course of all anesthetic regimens, suggesting a decrease in parasympathetic tone. We conclude that the most optimal anesthetic condition is achieved when N(2)O (50%) is added to the gas mixture.
C Constantinides; R Mean; B Janssen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2010     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-30     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2529-32     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Electrocardiography / methods
Equipment Design
Heart Rate*
Image Processing, Computer-Assisted
Mice, Inbred C57BL
Nitrous Oxide / administration & dosage*
Oxygen / administration & dosage*
Reproducibility of Results
Time Factors
Reg. No./Substance:
K50XQU1029/Nitrous Oxide; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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